发明申请
- 专利标题： Common ligand mimics: thiazolidinediones and rhodanines
- 专利标题（中）： 通用配体模拟物：噻唑烷二酮类和罗丹宁类
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申请号： US10081989申请日： 2002-02-21
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公开(公告)号： US20050042674A9公开(公告)日： 2005-02-24
- 发明人: Lin Yu , Qing Dong , Fabrice Pierre , Edcon Chang , Hengyuan Lang , Yong Qin , Yunfeng Fang , Mark Hansen , Maurizio Pellecchia
- 申请人： Lin Yu , Qing Dong , Fabrice Pierre , Edcon Chang , Hengyuan Lang , Yong Qin , Yunfeng Fang , Mark Hansen , Maurizio Pellecchia
- 主分类号： C07B61/00
- IPC分类号： C07B61/00 ; C07D417/06 ; C07D417/14 ; C07D521/00 ; G01N33/53 ; C07D413/02 ; C07K5/06 ; G01N33/543
摘要：
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand which compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.
公开/授权文献
- US20040009526A1 Common ligand mimics: thiazolidinediones and rhodanines 公开/授权日：2004-01-15
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