利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

49 条记录 (耗时 0.045 秒)

    Common ligand mimics: pseudothiohydantoins
    2.
    发明申请
    Common ligand mimics: pseudothiohydantoins 审中-公开
    普通配体模拟物：假硫代乙内酰脲

    公开(公告)号：US20050019825A9

    公开(公告)日：2005-01-27

    申请号：US10099136

    申请日：2002-03-15

    申请人： Qing Dong ,  Fabrice Pierre ,  Hengyuan Lang ,  Lin Yu ,  Mark Hansen ,  Daniel Sem ,  Maurizio Pellecchia

    发明人： Qing Dong ,  Fabrice Pierre ,  Hengyuan Lang ,  Lin Yu ,  Mark Hansen ,  Daniel Sem ,  Maurizio Pellecchia

    IPC分类号： C07B61/00 ,  C07D277/20 ,  C07D277/38 ,  C07D417/06 ,  C07D417/12 ,  G01N33/53 ,  C07D417/02 ,  G01N33/543

    CPC分类号： C07D277/20 ,  C07D417/06 ,  C07D417/12 ,  C40B40/00 ,  G01N2500/00

    摘要： The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand that compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.

    摘要翻译： 本发明提供了作为受体家族的共同配体的常见配体模拟物。 本发明还提供含有这些共同配体模拟物的双配体。 本发明的双配体通过构成双配体的共同配体模拟物和特异性配体的协同作用，提供配体与受体或受体家族结合的增强的亲和力和/或选择性。 本发明还提供了包含本发明的共同配体模拟物和双配位体的组合文库。 此外，本发明提供了制备本发明的共同配体模拟物和双配位体的方法以及用于测定本发明的组合文库的方法。

    Common ligand universal enzyme assay and compositions for use therein
    3.
    发明申请
    Common ligand universal enzyme assay and compositions for use therein 审中-公开
    普通配体通用酶测定法及其中使用的组合物

    公开(公告)号：US20050208613A1

    公开(公告)日：2005-09-22

    申请号：US11118016

    申请日：2005-04-29

    申请人： Yong Qin ,  Lin Yu ,  Mark Hansen ,  Eduard Sergienko ,  Bonnie Bertolaet ,  Daniel Sem

    发明人： Yong Qin ,  Lin Yu ,  Mark Hansen ,  Eduard Sergienko ,  Bonnie Bertolaet ,  Daniel Sem

    IPC分类号： C12N9/02 ,  G01N33/566 ,  C12Q1/26 ,  C07H19/207

    CPC分类号： C12N9/001 ,  C12Y103/01026 ,  G01N33/566 ,  G01N2333/90209 ,  G01N2500/02

    摘要： The present invention provides compositions containing a common ligand linked to a detectable moiety and provides methods for the preparation of such compositions. The present invention also provides methods for screening candidate ligands for binding to a NAD binding receptor, which include contacting a receptor with a candidate ligand and a composition of the invention followed by evaluation of receptor binding. The screening method of the present invention has broad applicability and can be used to screen large numbers of a wide variety of ligands. The present invention further provides methods for detecting the binding activity of a putative receptor, which include combining the putative receptor with a composition of the invention and evaluating the level of detectable moiety. The invention also provides kits useful for detection of receptors having NAD binding activity and for screening of candidate ligands that bind to a NAD binding receptor.

    摘要翻译： 本发明提供含有与可检测部分连接的共同配体的组合物，并提供制备这种组合物的方法。 本发明还提供了筛选用于结合NAD结合受体的候选配体的方法，其包括使受体与候选配体和本发明的组合物接触，然后评估受体结合。 本发明的筛选方法具有广泛的适用性，可用于筛选大量各种配体。 本发明还提供了用于检测推定受体的结合活性的方法，其包括将推定的受体与本发明的组合物结合并评估可检测部分的水平。 本发明还提供了可用于检测具有NAD结合活性的受体并用于筛选结合NAD结合受体的候选配体的试剂盒。

    VEHICLE INTERIOR ENVIRONMENT CONTROL
    4.
    发明公开
    VEHICLE INTERIOR ENVIRONMENT CONTROL 审中-公开

    公开(公告)号：US20230331061A1

    公开(公告)日：2023-10-19

    申请号：US18157863

    申请日：2023-01-23

    申请人： Lin Yu ,  Mary Clover Apelian

    发明人： Lin Yu ,  Mary Clover Apelian

    IPC分类号： B60H1/00

    CPC分类号： B60H1/00735 ,  B60H1/00742 ,  B60H1/00778 ,  B60H1/008 ,  B60H1/00985 ,  B60H1/0073 ,  B60H1/00878 ,  B60H2001/3266

    摘要： A computer-implemented process for controlling a vehicle interior includes detecting a previously defined situation that relates to an undesirable environmental condition of the vehicle interior, and assessing both a risk level and an urgency level, based on a vehicle sensor input. The process also includes generating a vehicle command based upon the detected previously defined situation, the assessed risk level, and assessed urgency level, and executing the generated vehicle command to control at least one of an engine, a window, and a heating, ventilation and air conditioning (HVAC) unit to modify an environmental condition of the vehicle interior.

    VEHICLE INTERIOR ENVIRONMENT CONTROL
    5.
    发明申请
    VEHICLE INTERIOR ENVIRONMENT CONTROL 有权

    公开(公告)号：US20210402846A1

    公开(公告)日：2021-12-30

    申请号：US17370512

    申请日：2021-07-08

    申请人： Lin Yu ,  Mary Clover Apelian

    发明人： Lin Yu ,  Mary Clover Apelian

    IPC分类号： B60H1/00

    摘要： A computer-implemented process for controlling a vehicle interior includes detecting a previously defined situation that relates to an undesirable environmental condition of the vehicle interior, and assessing both a risk level and an urgency level, based on a vehicle sensor input. The process also includes generating a vehicle command based upon the detected previously defined situation, the assessed risk level, and assessed urgency level, and executing the generated vehicle command to control at least one of an engine, a window, and a heating, ventilation and air conditioning (HVAC) unit to modify an environmental condition of the vehicle interior.

    Band
    6.
    外观设计
    Band 有权

    公开(公告)号：USD848894S1

    公开(公告)日：2019-05-21

    申请号：US29617629

    申请日：2017-09-15

    申请人： Lin Yu

    设计人： Lin Yu

    Method and apparatus of 8PSK modulation
    8.
    发明授权
    Method and apparatus of 8PSK modulation 有权
    8PSK调制方法和装置

    公开(公告)号：US07236543B2

    公开(公告)日：2007-06-26

    申请号：US10373485

    申请日：2003-02-24

    申请人： Jing Wang ,  Lin Yu ,  Qiang Zhang ,  Lai Qian

    发明人： Jing Wang ,  Lin Yu ,  Qiang Zhang ,  Lai Qian

    IPC分类号： H04L27/20 ,  H04L27/10 ,  H04B1/66 ,  H03C3/00 ,  G06K9/36

    CPC分类号： H04L27/2092 ,  H04L25/03859 ,  H04L27/2075

    摘要： 8PSK modulation methods and apparatuses are provided. In a first embodiment, product factors of symbol vectors and a coefficient of a shape filter are stored in a table and compressed by 8 times based on a law of a trigonometric function, wherein a method of table looking-up is used to replace a multiplication operation. In a second embodiment, all states of 8PSK modulation are stored in a table after shape filtering, and then the data of the states stored in the table are compressed based on a corresponding relationship of a law of a trigonometric function and an electrical level diversity, and then a table looking-up operation is performed. In a third embodiment, new modulated vectors are stored in a modulated phase table after simple 8PSK modulation and phase rotation, the modulated phase table is compressed by 4 times, and new modulated vectors are obtained by a table looking-up operation and data processing. Then, shape filtering is performed by utilizing a RAM coefficient filter. The 8PSK modulation methods and apparatuses are compatible with GSM systems and are capable of providing sufficient capability of data services and sufficiently extending a life cycle of prior GSM systems. It allows a service agent not only to save investment, but also to provide competitive services.

    摘要翻译： 提供了8PSK调制方法和装置。 在第一实施例中，符号向量的乘积因子和形状滤波器的系数被存储在表中，并且基于三角函数的定律被压缩8倍，其中使用表查找的方法来代替乘法 操作。 在第二实施例中，在形状滤波之后将8PSK调制的所有状态存储在表中，然后基于三角函数定律和电位分集的对应关系来压缩存储在表中的状态的数据， 然后执行表查找操作。 在第三实施例中，在简单的8PSK调制和相位旋转之后，将新的调制矢量存储在调制相位表中，将调制相位表压缩4倍，并通过表查找操作和数据处理获得新的调制向量。 然后，利用RAM系数滤波器进行形状滤波。 8PSK调制方法和装置与GSM系统兼容，并且能够提供足够的数据服务能力并充分延长先前GSM系统的生命周期。 它允许服务代理商不仅节省投资，而且还提供有竞争力的服务。

    Database systems, methods and computer program products including primary key and super key indexes for use with partitioned tables
    9.
    发明授权
    Database systems, methods and computer program products including primary key and super key indexes for use with partitioned tables 有权
    数据库系统，方法和计算机程序产品，包括与分区表一起使用的主键和超级键索引

    公开(公告)号：US06795821B2

    公开(公告)日：2004-09-21

    申请号：US09907333

    申请日：2001-07-17

    申请人： Lin Yu

    发明人： Lin Yu

    IPC分类号： G06F1730

    CPC分类号： G06F17/30584 ,  G06F17/30371 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99952

    摘要： Database systems, methods and/or computer program products that include a database management system and a database having partitioned tables. The partitioned tables include at least two entity tables and a relationship table where the relationship table has a child-to-parent relationship to each of the entity tables. Keys and indices are defined for the entity tables and the relationship table so that the database management system maintains referential integrity between the relationship table and the entity tables to thereby enforce the child-parent relationship. The keys and indices include a primary key which includes one or more columns of a corresponding entity table. The columns of the primary key, however, does not include columns which are used only for partitioning the entity table. A super key includes the columns of the primary key of a corresponding entity table and one or more columns of the entity table which are used only for partitioning the entity table A super key index of the corresponding entity table is based on the super key. Foreign keys are defined for the relationship table corresponding to the primary keys of the entity tables which are related by the relationship table.

    摘要翻译： 包括数据库管理系统和具有分区表的数据库的数据库系统，方法和/或计算机程序产品。 分区表至少包括两个实体表和关系表，其中关系表与每个实体表具有子对象关系。 密钥和索引是为实体表和关系表定义的，以便数据库管理系统维护关系表和实体表之间的引用完整性，从而实现子 - 父关系。 密钥和索引包括主键，其包括相应实体表的一个或多个列。 但是，主键的列不包括仅用于分区实体表的列。 超级密钥包括对应实体表的主键列和实体表的一列或多列，这些列仅用于对实体表进行分区。相应实体表的超级密钥索引基于超级密钥。 为与关系表相关的实体表的主键对应的关系表定义外键。

    Conjugates comprising galactose &agr;1,3 galactosyl epitopes and methods of using same
    10.
    发明授权
    Conjugates comprising galactose &agr;1,3 galactosyl epitopes and methods of using same 失效
    包含半乳糖α1,3半乳糖基表位的缀合物及其使用方法

    公开(公告)号：US06399578B1

    公开(公告)日：2002-06-04

    申请号：US09457913

    申请日：1999-12-08

    申请人： Richard M. Jack ,  David S. Jones ,  Lin Yu

    发明人： Richard M. Jack ,  David S. Jones ,  Lin Yu

    IPC分类号： A01N4304

    CPC分类号： C07H15/26 ,  A61K47/54 ,  A61K47/545 ,  C07H15/08 ,  C07H15/18

    摘要： This invention provides conjugates useful for xenotransplantation which comprise a galactose &agr;1,3 galactosyl (&agr;Gal) epitope conjugated to a valency platform molecule, preferably a chemically defined valency platform molecule which allows precise valency. The invention also provides compositions comprising these conjugates, and methods (such as methods for inducing tolerance) using these conjugates and compositions.

    摘要翻译： 本发明提供了可用于异种移植的缀合物，其包含与价态平台分子缀合的半乳糖α1,3半乳糖基（αGal）表位，优选化学定义的价态平台分子，其允许精确的化合价。 本发明还提供包含这些缀合物的组合物，以及使用这些缀合物和组合物的方法（例如诱导耐受性的方法）。