发明申请
US20050059092A1 Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
有权
基于丝裂原活化蛋白激酶磷酸化的阿尔茨海默病诊断
- 专利标题： Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
- 专利标题（中）： 基于丝裂原活化蛋白激酶磷酸化的阿尔茨海默病诊断
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申请号： US10469164申请日： 2002-02-27
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公开(公告)号： US20050059092A1公开(公告)日： 2005-03-17
- 发明人: Wei-Qin Zhao , Daniel Alkon
- 申请人： Wei-Qin Zhao , Daniel Alkon
- 申请人地址： US MD Rockville 20850
- 专利权人： Blanchette Rockefeller Neursociences Institute
- 当前专利权人： Blanchette Rockefeller Neursociences Institute
- 当前专利权人地址： US MD Rockville 20850
- 国际申请： PCT/US02/05672 WO 20020227
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K45/00 ; A61P25/28 ; A61P43/00 ; C12N5/10 ; C12Q1/02 ; C12Q1/48 ; G01N33/15 ; G01N33/53 ; G01N33/68 ; G01N33/567
摘要：
A method of diagnosing Alzheimer's disease in a patient comprises determining whether the phosphorylation level of an indicator protein in cells of the patient after stimulus with an activator compound is abnormally elevated as compared to a basal phosphorylation level, the indicator protein being e.g. Erk1/2 and the activator compound being e.g. bradykinin.