发明申请
US20050065325A1 Assay for YKL-40 as a marker for degradation of mammalian connective tissue matrices
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测定YKL-40作为哺乳动物结缔组织基质降解的标志物
- 专利标题： Assay for YKL-40 as a marker for degradation of mammalian connective tissue matrices
- 专利标题（中）： 测定YKL-40作为哺乳动物结缔组织基质降解的标志物
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申请号： US10648811申请日： 2003-08-25
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公开(公告)号： US20050065325A1公开(公告)日： 2005-03-24
- 发明人: Paul Price , Julia Johansen
- 申请人： Paul Price , Julia Johansen
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K38/00 ; A61K39/395 ; A61P29/00 ; A61P43/00 ; C07K14/47 ; C07K16/18 ; G01N33/564 ; G01N33/574 ; G01N33/577 ; G01N33/68 ; C07K16/00
摘要：
The invention is a method of identifying the presence of a disease state in a mammal which is associated with degradation of connective tissue in the mammal which contains the protein known as YKL-40. The method is a competitive immunoassay for YKL-40. It can be used, for example, to identify the presence of inflammatory or degenerative joint disease and tumor metastasis (to the extent it can be correlated to serum YKL-40 levels). Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.
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