发明申请
- 专利标题: Long lasting fusion peptide inhibitors of viral infection
- 专利标题(中): 长期的病毒感染融合肽抑制剂
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申请号: US10950010申请日: 2004-09-24
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公开(公告)号: US20050070475A1公开(公告)日: 2005-03-31
- 发明人: Dominique Bridon , Robert Dufresne , Nissab Boudjellab , Martin Robitaille , Peter Milner
- 申请人: Dominique Bridon , Robert Dufresne , Nissab Boudjellab , Martin Robitaille , Peter Milner
- 申请人地址: CA Montreal
- 专利权人: ConjuChem, Inc.
- 当前专利权人: ConjuChem, Inc.
- 当前专利权人地址: CA Montreal
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61P31/12 ; A61P31/16 ; A61P31/18 ; C07K14/00 ; C07K14/155 ; C07K14/16 ; A61K38/17 ; C07K14/47
摘要:
Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
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