发明申请
- 专利标题： DSP-5 dual-specificity phosphatase
- 专利标题（中）： DSP-5双特异性磷酸酶
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申请号： US10644554申请日： 2003-08-19
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公开(公告)号： US20050075489A1公开(公告)日： 2005-04-07
- 发明人: Ralf Luche , Bo Wei
- 申请人： Ralf Luche , Bo Wei
- 申请人地址： US WA Bothell 98021
- 专利权人： CEPTYR, Inc.
- 当前专利权人： CEPTYR, Inc.
- 当前专利权人地址： US WA Bothell 98021
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K39/395 ; A61K45/00 ; A61P3/00 ; A61P35/00 ; A61P37/06 ; A61P37/08 ; A61P43/00 ; C07K16/40 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/06 ; C12N5/10 ; C12N9/16 ; C12N15/09 ; C12N15/55 ; C12P21/08 ; C12Q1/68 ; G01N33/15 ; G01N33/53 ; G01N33/566 ; G01N33/577 ; G01N33/58 ; C07K16/18
摘要：
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-5, and polypeptide variants thereof that stimulate dephosphorylation of DSP-5 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-5 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
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