A system and method for buffering bidirectional digital I/O lines. The system (e.g., data acquisition system) may comprise a device including circuitry for buffering bidirectional digital lines. A first IC of the device preferably includes a first and a second bidirectional buffer coupled to a first bidirectional digital I/O line, and a second IC of the device preferably includes a third bidirectional buffer. The first IC and the second IC may also each include a control unit to control a driving direction of the corresponding bidirectional buffers independently to change the direction of a data flow through the first bidirectional digital I/O line from a first direction to a second direction. The driving direction of the bidirectional buffers may be changed at different times in a particular sequence, and the order may depend on whether the direction change is from the output direction to the input direction or vice versa.