发明申请
US20050085644A1 Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same
审中-公开
新型3-芳基-2,5-二羟基-1,4-苯醌衍生物及其制备方法和含有它们的药物组合物
- 专利标题： Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same
- 专利标题（中）： 新型3-芳基-2,5-二羟基-1,4-苯醌衍生物及其制备方法和含有它们的药物组合物
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申请号： US10503527申请日： 2003-02-04
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公开(公告)号： US20050085644A1公开(公告)日： 2005-04-21
- 发明人: Alexandra Dassonville , Anne Breteche , Muriel Duflos , Guillaume Le Baut , Bruno Pfeiffer , Pierre Renard , Nigel Levens , Bernadette Husson-Robert
- 申请人： Alexandra Dassonville , Anne Breteche , Muriel Duflos , Guillaume Le Baut , Bruno Pfeiffer , Pierre Renard , Nigel Levens , Bernadette Husson-Robert
- 优先权： FR02/01409 20020206
- 国际申请： PCT/FR03/00331 WO 20030204
- 主分类号： A61K31/122
- IPC分类号： A61K31/122 ; A61K31/222 ; A61K31/4402 ; A61P3/10 ; C07C45/00 ; C07C45/28 ; C07C46/00 ; C07C46/10 ; C07C50/28 ; C07C50/30 ; C07D213/50 ; C07C50/38 ; C07D207/00 ; C07D213/46
摘要：
Compound of formula (I): wherein: R1 and R2, which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R4 represents hydrogen or alkyl, R5 represents hydrogen, alkyl, aryl or heteroaryl, R3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.
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