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公开(公告)号:US20220177418A1
公开(公告)日:2022-06-09
申请号:US17599083
申请日:2020-03-27
申请人: The Regents of the University of California , The United States Government represented by the Department of Veterans Affairs
IPC分类号: C07C233/13 , C07C233/40 , C07C233/91 , C07C235/76 , C07C255/46 , C07C307/04 , C07C49/537 , C07C49/697 , C07C69/618 , C07D207/273 , C07D207/38 , C07D211/70 , C07D213/46 , C07D307/46 , C07D303/32 , C07D263/32
摘要: The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.
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公开(公告)号:US10752596B2
公开(公告)日:2020-08-25
申请号:US16150989
申请日:2018-10-03
申请人: JAPAN TOBACCO INC.
IPC分类号: C07D241/12 , C07D213/46 , A61P19/06 , C07D405/10 , A61P43/00 , A61K31/4965 , C07D217/16 , A61K31/497 , C07D213/55 , A61K31/4433 , A61K31/4418 , C07D405/04 , A61K31/472
摘要: The invention provides a compound having a GLUT9 inhibitory activity. The compound is of Formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
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公开(公告)号:US20200172493A1
公开(公告)日:2020-06-04
申请号:US16698332
申请日:2019-11-27
发明人: Boyd M. Goodson , Eduard Y. Chekmenev , Bryce E. Kidd , Jamil A. Mashni , Miranda Limbach , Yuqing Hou , Fan Shi
IPC分类号: C07D233/60 , G01R33/28 , C07D401/06 , C07D241/12 , C07D213/46 , C07D213/63 , C07F9/6506 , B01J31/12
摘要: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
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公开(公告)号:US10227323B2
公开(公告)日:2019-03-12
申请号:US15023337
申请日:2014-09-19
发明人: Bing Wang , Daniel Chu , Alexander James Bridges
IPC分类号: C07D471/12 , C07D471/04 , C07D491/056 , C07D211/46 , C07D205/02 , C07D231/56 , C07D215/06 , C07D319/18 , C07D405/14 , C07D309/10 , C07D311/12 , C07D333/16 , C07D333/62 , C07D235/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D205/04 , C07D265/30 , C07D277/22 , C07D209/04 , C07D277/62 , C07D295/12 , C07D213/46 , C07D213/64 , C07D307/79 , C07B59/00 , C07D213/56 , C07D213/61 , C07D235/08 , C07D277/30 , C07D295/13 , C07D305/08 , C07D307/81 , C07D309/12 , C07D311/58 , C07D333/24 , C07D333/60 , C07D405/06 , C07D471/08 , C07D487/08
摘要: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
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5.
公开(公告)号:US20180215745A1
公开(公告)日:2018-08-02
申请号:US15851434
申请日:2017-12-21
IPC分类号: C07D413/12 , C07D231/56 , C07D215/18 , C07D333/06 , C07D241/42 , C07D277/24 , C07D277/64 , C07D213/46 , C07D307/79 , C07D263/56 , C07D261/20 , C07D239/74 , C07D237/28 , C07D235/08 , C07D217/02 , C07D209/08 , C07D407/12 , C07D333/28 , C07D333/10 , C07D319/18
CPC分类号: C07D413/12 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/47 , A61K31/502 , A61K31/517 , C07D209/08 , C07D213/46 , C07D215/18 , C07D217/02 , C07D231/56 , C07D235/08 , C07D237/28 , C07D239/74 , C07D241/42 , C07D261/20 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/79 , C07D319/18 , C07D333/06 , C07D333/10 , C07D333/28 , C07D407/12
摘要: Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
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6.
公开(公告)号:US20180044286A1
公开(公告)日:2018-02-15
申请号:US15549743
申请日:2016-02-11
发明人: Samarjit PATNAIK , Mercedes TAYLOR , Raul Rolando CALVO , Juan Jose MARUGAN , Noel SOUTHALL , Wei ZHENG , Marc FERRER-ALEGRE , Seameen DEHDASTHI , Patricia DRANCHAK , Fannie CHEN , Yiannis IOANNOU
IPC分类号: C07C311/21 , C07D207/335 , C07D213/46 , C07D233/64
CPC分类号: C07C311/21 , A61K31/165 , A61K31/4164 , A61K31/44 , C07D207/335 , C07D213/46 , C07D233/64
摘要: Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula 1:
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公开(公告)号:US09839216B2
公开(公告)日:2017-12-12
申请号:US15107388
申请日:2014-12-19
发明人: Thomas Pitterna , Andre Stoller , Andrew Edmunds
IPC分类号: C07D213/46 , C07C233/64 , A01N33/06 , A01N37/24 , C07C255/57 , C07C237/42 , C07C237/44 , C07D213/81 , A01N37/46 , A01N43/40 , A01N37/34 , C07C255/60 , C07D213/89
CPC分类号: A01N37/24 , A01N37/34 , A01N37/46 , A01N43/40 , C07C237/42 , C07C237/44 , C07C255/57 , C07C255/60 , C07D213/81 , C07D213/89
摘要: The present invention relates to bis-amide derivatives as defined by the compound of formula (I), to processes and intermediates for preparing them, to methods of using them to control insect, acarine, nematode and mollusc pests, and to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising them.
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公开(公告)号:US09718780B2
公开(公告)日:2017-08-01
申请号:US14961026
申请日:2015-12-07
申请人: Purdue Pharma L.P.
发明人: Laykea Tafesse , Jiangchao Yao
IPC分类号: C07D213/24 , C07D239/24 , A61K31/47 , A61K31/505 , C07D213/50 , C07D213/81 , C07D213/30 , C07D213/46 , C07D213/56 , C07D213/57
CPC分类号: C07D213/50 , C07D213/24 , C07D213/30 , C07D213/46 , C07D213/56 , C07D213/57 , C07D213/81
摘要: The invention relates to substituted pyridine and pyrimidine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1, R2a, R2b, A1, A2, X, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
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公开(公告)号:US09334238B2
公开(公告)日:2016-05-10
申请号:US14389125
申请日:2013-03-27
申请人: BASF SE
发明人: Nina Gertrud Bandur , Ralph Paulini , Florian Kaiser , Arun Narine , Joachim Dickhaut , Karsten Körber
IPC分类号: A61K31/4427 , C07D401/06 , C07D213/50 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/76 , A01N43/78 , C07D401/14 , C07D405/06 , C07D413/06 , C07D417/06 , C07D213/61 , C07D213/46 , A01N43/84 , C07D213/48 , C07D213/52 , C07D213/53
CPC分类号: C07D213/50 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/76 , A01N43/78 , A01N43/84 , C07D213/46 , C07D213/48 , C07D213/52 , C07D213/53 , C07D213/61 , C07D401/06 , C07D401/14 , C07D405/06 , C07D413/06 , C07D417/06
摘要: The invention relates to pyridylidene compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to methods and uses of these N-substituted pyridylidene compounds, and of compositions comprising thereof, for combating and controlling animal pests. Furthermore the invention relates also to pesticidal methods of applying such N-substituted pyridylidene compounds.The N-substituted pyridylidene compounds of the present invention are defined by the following formula I: wherein X, Het, R1, R2, R3, R4 and R6 are defined as in the description.
摘要翻译: 本发明涉及式(I)的吡啶亚基化合物,其涉及其对映体,非对映异构体和盐以及包含这些化合物的组合物。 本发明还涉及这些N-取代的吡啶亚基化合物及其组合物的方法和用途,用于对抗和控制动物害虫。 此外,本发明还涉及施用这种N-取代的吡啶亚基化合物的杀虫方法。 本发明的N-取代的吡啶亚基化合物由下式I定义:其中X,Het,R 1,R 2,R 3,R 4和R 6如描述中所定义。
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10.
公开(公告)号:US20160122327A1
公开(公告)日:2016-05-05
申请号:US14897968
申请日:2014-06-18
申请人: BASF SE
发明人: Christian WINTER , Joachim RHEINHEIMER , Antje WOLF , Manojkumar POONOTH , Violeta TERTERYAN , Christine WIEBE , Doris KREMZOW-GRAW , Franz ROEHL , Wassilios GRAMMENOS , Sebastian Georgios ROHRER , Andy WEIJA , Claudia ROSENBAUM
IPC分类号: C07D405/04 , A01N47/12 , C07D213/46 , C07D239/26 , A01N47/24 , C07D401/04 , C07D249/10 , C07D263/32 , C07D231/12 , C07C281/02
CPC分类号: C07D405/04 , A01N47/12 , A01N47/24 , A01N47/28 , C07C251/38 , C07C271/16 , C07C275/24 , C07C281/02 , C07D213/06 , C07D213/46 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/20 , C07D239/26 , C07D239/34 , C07D249/10 , C07D261/12 , C07D263/32 , C07D277/34 , C07D401/04
摘要: The present invention relates to novel strobilurine type compounds I, processes for preparing these compounds, a use of compounds of the formula I and/or their agriculturally useful salts for controlling phytopathogenic fungi, to compositions comprising at least one such compound, to plant health applications, and to seeds coated with at least one such compound.
摘要翻译: 本发明涉及新型的倍半萜类化合物I,制备这些化合物的方法,式I化合物和/或其农业用盐控制植物病原真菌的用途,至少含有一种此类化合物的组合物,用于植物健康应用 以及用至少一种这样的化合物包衣的种子。
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