Thiadiazine derivatives and use thereof as positive ampa receptor modulators
    2.
    发明申请
    Thiadiazine derivatives and use thereof as positive ampa receptor modulators 失效
    噻二嗪衍生物及其作为正安培受体调节剂的用途

    公开(公告)号:US20070004709A1

    公开(公告)日:2007-01-04

    申请号:US10555743

    申请日:2004-05-04

    IPC分类号: A61K31/549 C07D498/02

    CPC分类号: C07D513/04

    摘要: Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR′ and SO2NHR′ wherein R′ represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.

    摘要翻译: 式(I)化合物:其中:A表示噻吩基,呋喃基,吡咯基,氧硫杂环戊烷,噻唑,异噻唑,恶唑或咪唑,表示单键或双键,R <1 表示任选被一个或多个选自卤素或(C 1 -C 6)烷基的基团取代的直链或支链(C 1 -C 6 -C 6)烷基, -C 6 -C 6烷氧基 - (C 1 -C 6 -C 6)烷基,R 2表示氢或直链或 任选被一个或多个卤素取代的支链(C 1 -C 6 -C 6)烷基,R 3 3表示氢或选自直链或 支链(C 1 -C 6 -C 6)烷基,CONHR'和SO 2 NHR',其中R'表示直链或支链(C 1 -C 6) 1 -C 6烷基,其对映体和非对映异构体及其加成盐w 具有药学上可接受的酸或碱。 含有该药物的药物,可用作AMPA抑制剂。