An interruption control system includes a first input/output interruption controller, a second input/output interruption controller, and an interruption control device bus. The first input/output interruption controller is coupled to a first peripheral device and a south bridge chip, and asserts a wake-up signal to the south bridge chip in response to a first interrupt signal issued by the first peripheral device so as to deactivate a power-saving state of the computer system. The second input/output interruption controller is coupled to a second peripheral device and a north bridge chip, and asserts a third interrupt signal in response to a second interrupt signal issued by the second peripheral device. Via the interruption control device bus, the third interrupt signal is transmitted from the second input/output interruption controller to the first input/output interruption controller, wherein the first input/output interruption controller asserts the wake-up signal to deactivate the power-saving state of the computer system in response to the third interrupt signal.