发明申请
- 专利标题： Hyaluronic acid oligosaccharide fractions and drugs containing the same
- 专利标题（中）： 透明质酸寡糖组分和含有相同的药物
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申请号： US10312879申请日： 2001-07-06
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公开(公告)号： US20050090661A1公开(公告)日： 2005-04-28
- 发明人: Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
- 申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
- 申请人地址： JP Tokyo 103-0023
- 专利权人： Seikagaku Corporation
- 当前专利权人： Seikagaku Corporation
- 当前专利权人地址： JP Tokyo 103-0023
- 优先权： JP2000-206404 20000707; JP2000-247840 20000817
- 国际申请： PCT/JP01/05918 WO 20010706
- 主分类号： A61K31/702
- IPC分类号： A61K31/702 ; A61K31/728 ; A61P1/04 ; A61P1/16 ; A61P43/00 ; C07H7/033 ; C08B37/08 ; C08B37/00
摘要：
Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
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