发明申请
- 专利标题： Method for high-throughput screening assay sample preparation and analysis
- 专利标题（中）： 高通量筛选测定方法样品制备和分析方法
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申请号： US10719961申请日： 2003-11-21
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公开(公告)号： US20050112766A1公开(公告)日： 2005-05-26
- 发明人: Richard Bruce , Francisco Torres , Alan Bell , Eric Peeters
- 申请人： Richard Bruce , Francisco Torres , Alan Bell , Eric Peeters
- 专利权人： Palo Alto Research Center
- 当前专利权人： Palo Alto Research Center
- 主分类号： B01J19/00
- IPC分类号： B01J19/00 ; C40B50/08 ; G01N25/48 ; G01N37/00 ; G01N31/10
摘要：
A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.