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1.发明申请公开(公告)号：US20060078999A1
公开(公告)日：2006-04-13
申请号：US11149632
申请日：2005-06-10
申请人： Alan Bell , Richard Bruce , Scott Elrod , Eric Peeters , Francisco Torres
发明人： Alan Bell , Richard Bruce , Scott Elrod , Eric Peeters , Francisco Torres
IPC分类号： G01K17/02
CPC分类号： B82Y15/00 , G01N25/4846 , G01N25/4866 , Y10S977/957 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.
摘要翻译： 用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米尺度计。 热测量设备连接到检测电子设备。 该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。 这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。 然后用检测电子元件测量在合并溶液中发生的热变化。
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公开(公告)号：US20060159585A1
公开(公告)日：2006-07-20
申请号：US11037666
申请日：2005-01-18
申请人： Francisco Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory Anderson , Alan Bell , Richard Bruce
发明人： Francisco Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory Anderson , Alan Bell , Richard Bruce
IPC分类号： G01N25/20
CPC分类号： G01N25/482 , G01K17/006
摘要： A detection system includes a detection device and an anti-evaporation device. The detection device comprises a region configured to merge at least two small drops and to detect a potential transient signal generated by the merger of the drops. The an anti-evaporation is configured to enclose the region and limit evaporation from the region. A method for detecting a signal includes the following steps: depositing drops of potentially reactive chemical solutions on a detection device within a drop-merging region; placing an anti-evaporation device over the drop-merging region to form a seal around the drop-merging region; merging the drops of potentially reactive chemical solutions; and measuring a signal occurring within the merged solution drops.
摘要翻译： 检测系统包括检测装置和防蒸发装置。 检测装置包括被配置为合并至少两个小液滴并且检测由液滴的合并产生的潜在瞬态信号的区域。 防蒸发被配置为包围该区域并限制该区域的蒸发。 一种用于检测信号的方法包括以下步骤：在滴合并区域内的检测装置上沉积潜在的反应性化学溶液滴; 将防蒸发装置放置在熔融合并区域上以形成围绕滴合并区域的密封; 合并潜在的活性化学溶液滴; 并且测量在合并的溶液中发生的信号下降。
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3.发明申请公开(公告)号：US20050112766A1
公开(公告)日：2005-05-26
申请号：US10719961
申请日：2003-11-21
申请人： Richard Bruce , Francisco Torres , Alan Bell , Eric Peeters
发明人： Richard Bruce , Francisco Torres , Alan Bell , Eric Peeters
CPC分类号： G01N25/4866 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.
摘要翻译： 公开了用于高通量筛选测定样品制备和用于鉴定药物靶标和文库化合物之间的结合的测试的方法，用于测量结合反应焓的量热器件。 该方法包括将文库化合物与指定溶剂混合，并将目标化合物溶液与第二指定溶剂混合在量热装置上。 文库化合物/溶剂与目标化合物/溶剂溶液合并，文库化合物/溶剂溶液也与量热装置上的第三溶剂溶液合并。 对于两个合并的溶液检测反应热，并进行比较。
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公开(公告)号：US20050254994A1
公开(公告)日：2005-11-17
申请号：US11167612
申请日：2005-06-27
申请人： Alan Bell , Richard Bruce , Eric Peeters , Michal Wolkin , Dirk Bruyker
发明人： Alan Bell , Richard Bruce , Eric Peeters , Michal Wolkin , Dirk Bruyker
CPC分类号： G01K7/30 , G01K17/00 , G01N25/482
摘要： Thermal sensing devices can include two subsets of thermal sensors connected in a bridge by circuitry on the same support layer or surface with the sensors. Each thermal sensor can be formed in a patterned layer of semiconductor material, and the bridge circuitry can include leads formed in a patterned layer of conductive material, over or under the semiconductor layer. In one implementation, the bridge circuitry includes conductive portions that extend across and electrically contact the lower surface of each sensor's semiconductor slab. The bridge circuitry can also include pads that can be electrically contacted, such as by pogo pins. The device's reaction surface can be spaced apart from or over the thermal sensors. The device's components can be shaped and positioned so that the bridge's offset voltage is below the sensitivity level required for an application, such as by left-right symmetry about an axis.
摘要翻译： 热感测装置可以包括通过与传感器相同的支撑层或表面上的电路在桥中连接的两个热传感器子集。 每个热传感器可以形成在半导体材料的图案化层中，并且桥接电路可以包括形成在导电材料的图案化层中的引线，在半导体层之上或之下。 在一个实施方式中，桥接电路包括导电部分，其延伸并且电接触每个传感器的半导体板的下表面。 桥接电路还可以包括可以电接触的焊盘，例如通过弹簧销。 设备的反应表面可以与热传感器间隔开或超过热传感器。 该装置的部件可以被成形和定位，使得桥的偏移电压低于应用所需的灵敏度水平，例如通过关于轴的左右对称。
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公开(公告)号：US20050265898A1
公开(公告)日：2005-12-01
申请号：US11167635
申请日：2005-06-27
申请人： Alan Bell , Richard Bruce , Eric Peeters
发明人： Alan Bell , Richard Bruce , Eric Peeters
CPC分类号： G01K7/30 , B82Y15/00 , G01K17/00 , G01N25/482 , G01N25/4846 , G01N25/4866
摘要： Thermal detectors and thermal sensing cells can include a region of a support layer or support structure. Within the region can be reaction surfaces or other reaction regions, as well as contact pads and circuitry connecting the contact pads to other components. Also, a cell region can include a structure with reaction regions, contact pads, and control/detection circuitry connected to the contact pads; the control/detection circuitry controls occurrence of reactions in response to control signals, such as by drop merging, and also allows electrical detection of thermal signals from the reaction regions. The control/detection circuitry can include reaction control components such as drop merger electrodes and also thermal sensors such as thermistors, or it can include control/sensor elements such as semiconductor slabs that perform both functions. Each cell in an array can have control/detection circuitry that does not extend or connect outside the cell except through contact pads.
摘要翻译： 热检测器和热感测单元可以包括支撑层或支撑结构的区域。 该区域内可以是反应表面或其它反应区域，以及接触焊盘和将接触焊盘连接到其它部件的电路。 此外，电池区域可以包括具有反应区域，接触焊盘和连接到接触焊盘的控制/检测电路的结构; 控制/检测电路控制响应于控制信号的反应的发生，例如通过下降合并，并且还允许来自反应区域的热信号的电检测。 控制/检测电路可以包括反应控制部件，例如液滴合并电极和热敏传感器，例如热敏电阻，或者它可以包括执行这两个功能的控制/传感器元件，例如半导体板。 阵列中的每个单元都可以具有控制/检测电路，除了通过接触焊盘之外，它们不会扩展或连接到电池外部。
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公开(公告)号：US07473031B2
公开(公告)日：2009-01-06
申请号：US11167748
申请日：2005-06-27
申请人： Michal V. Wolkin , Dirk De Bruyker , Eric Peeters , Alan Bell
发明人： Michal V. Wolkin , Dirk De Bruyker , Eric Peeters , Alan Bell
CPC分类号： G01K7/30 , B82Y15/00 , G01K17/00 , G01N25/482 , G01N25/4846 , G01N25/4866
摘要： Thermal sensors for calorimetry can include vanadium oxide, heavily p-doped amorphous silicon, or other materials with high temperature coefficients of resistivity. Such thermal sensors can have low noise equivalent temperature difference (NETD). For example, a thermal sensor with NETD no greater than 100 μK over a bandwidth range of approximately 3 Hz or more can include a thermistor including vanadium oxide sputtered at room temperature under conditions that yield primarily V2O5; more specifically, the NETD can be no greater than 35 μK, or even 10 μK over a bandwidth range of approximately 3 Hz or more. If a low noise thermal sensor has NETD no greater than 50 μK over such a bandwidth range, a low noise output circuitry connected to its thermistor can provide an electrical output signal that includes information about input thermal signal peaks with amplitude of approximately 100 μK.
摘要翻译： 用于量热法的热传感器可以包括氧化钒，重掺杂非晶硅或具有高温电阻系数的其它材料。 这样的热传感器可以具有低噪声等效温差（NETD）。 例如，在大约3Hz以上的带宽范围内，NETD不大于100μKK的热传感器可以包括在主要产生V 2 O 5的条件下在室温下溅射的包含氧化钒的热敏电阻; 更具体地说，在大约3Hz以上的带宽范围内，NETD可以不大于35μK，甚至10μK。 如果低噪声热传感器在这样的带宽范围内的NETD不超过50μK，则连接到其热敏电阻的低噪声输出电路可以提供电输出信号，其包括关于具有大约100μKK的振幅的输入热信号峰值的信息。
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公开(公告)号：US07833800B2
公开(公告)日：2010-11-16
申请号：US11167612
申请日：2005-06-27
申请人： Alan Bell , Richard H. Bruce , Eric Peeters , Michal V. Wolkin , Dirk De Bruyker
发明人： Alan Bell , Richard H. Bruce , Eric Peeters , Michal V. Wolkin , Dirk De Bruyker
IPC分类号： G01N33/00
CPC分类号： G01K7/30 , G01K17/00 , G01N25/482
摘要： Thermal sensing devices can include two subsets of thermal sensors connected in a bridge by circuitry on the same support layer or surface with the sensors. Each thermal sensor can be formed in a patterned layer of semiconductor material, and the bridge circuitry can include leads formed in a patterned layer of conductive material, over or under the semiconductor layer. In one implementation, the bridge circuitry includes conductive portions that extend across and electrically contact the lower surface of each sensor's semiconductor slab. The bridge circuitry can also include pads that can be electrically contacted, such as by pogo pins. The device's reaction surface can be spaced apart from or over the thermal sensors. The device's components can be shaped and positioned so that the bridge's offset voltage is below the sensitivity level required for an application, such as by left-right symmetry about an axis.
摘要翻译： 热感测装置可以包括通过与传感器相同的支撑层或表面上的电路在桥中连接的两个热传感器子集。 每个热传感器可以形成在半导体材料的图案化层中，并且桥接电路可以包括形成在导电材料的图案化层中的引线，在半导体层之上或之下。 在一个实施方式中，桥接电路包括导电部分，其延伸并且电接触每个传感器的半导体板的下表面。 桥接电路还可以包括可以电接触的焊盘，例如通过弹簧销。 设备的反应表面可以与热传感器间隔开或超过热传感器。 该装置的部件可以被成形和定位，使得桥的偏移电压低于应用所需的灵敏度水平，例如通过关于轴的左右对称。
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公开(公告)号：US07754492B2
公开(公告)日：2010-07-13
申请号：US11167635
申请日：2005-06-27
申请人： Alan Bell , Richard H. Bruce , Eric Peeters
发明人： Alan Bell , Richard H. Bruce , Eric Peeters
IPC分类号： G01N33/00
CPC分类号： G01K7/30 , B82Y15/00 , G01K17/00 , G01N25/482 , G01N25/4846 , G01N25/4866
摘要： Thermal detectors and thermal sensing cells can include a region of a support layer or support structure. Within the region can be reaction surfaces or other reaction regions, as well as contact pads and circuitry connecting the contact pads to other components. Also, a cell region can include a structure with reaction regions, contact pads, and control/detection circuitry connected to the contact pads; the control/detection circuitry controls occurrence of reactions in response to control signals, such as by drop merging, and also allows electrical detection of thermal signals from the reaction regions. The control/detection circuitry can include reaction control components such as drop merger electrodes and also thermal sensors such as thermistors, or it can include control/sensor elements such as semiconductor slabs that perform both functions. Each cell in an array can have control/detection circuitry that does not extend or connect outside the cell except through contact pads.
摘要翻译： 热检测器和热感测单元可以包括支撑层或支撑结构的区域。 该区域内可以是反应表面或其它反应区域，以及接触焊盘和将接触焊盘连接到其它部件的电路。 此外，电池区域可以包括具有反应区域，接触焊盘以及连接到接触焊盘的控制/检测电路的结构; 控制/检测电路控制响应于控制信号的反应的发生，例如通过下降合并，并且还允许来自反应区域的热信号的电检测。 控制/检测电路可以包括反应控制部件，例如液滴合并电极和热敏传感器，例如热敏电阻，或者它可以包括执行这两个功能的控制/传感器元件，例如半导体板。 阵列中的每个单元都可以具有控制/检测电路，除了通过接触焊盘之外，它们不会扩展或连接到电池外部。
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公开(公告)号：US20050238080A1
公开(公告)日：2005-10-27
申请号：US11167748
申请日：2005-06-27
申请人： Michal Wolkin , Dirk Bruyker , Eric Peeters , Alan Bell
发明人： Michal Wolkin , Dirk Bruyker , Eric Peeters , Alan Bell
CPC分类号： G01K7/30 , B82Y15/00 , G01K17/00 , G01N25/482 , G01N25/4846 , G01N25/4866
摘要： Thermal sensors for calorimetry can include vanadium oxide, heavily p-doped amorphous silicon, or other materials with high temperature coefficients of resistivity. Such thermal sensors can have low noise equivalent temperature difference (NETD). For example, a thermal sensor with NETD no greater than 100 μK over a bandwidth range of approximately 3 Hz or more can include a thermistor including vanadium oxide sputtered at room temperature under conditions that yield primarily V2O5; more specifically, the NETD can be no greater than 35 μK, or even 10 μK over a bandwidth range of approximately 3 Hz or more. If a low noise thermal sensor has NETD no greater than 50 μK over such a bandwidth range, a low noise output circuitry connected to its thermistor can provide an electrical output signal that includes information about input thermal signal peaks with amplitude of approximately 100 μK.
摘要翻译： 用于量热法的热传感器可以包括氧化钒，重掺杂非晶硅或具有高温电阻系数的其它材料。 这样的热传感器可以具有低噪声等效温差（NETD）。 例如，在约3Hz以上的带宽范围内，NETD不大于100μKK的热传感器可以包括在室温下溅射的氧化钒的热敏电阻，其主要产生V 2 O 2， SUB> 5
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10.发明授权Transmucosal drug delivery device and method including chemical permeation enhancers 有权粘膜下药物递送装置和方法包括化学渗透促进剂公开(公告)号：US08882748B2
公开(公告)日：2014-11-11
申请号：US12576087
申请日：2009-10-08
申请人： Scott Uhland , Eric Peeters , Hussain Fatakdawala
发明人： Scott Uhland , Eric Peeters , Hussain Fatakdawala
CPC分类号： A61M31/002 , A61K9/0036
摘要： Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.
摘要翻译： 提供了用于经粘膜药物递送的装置和方法。 透粘膜药物递送装置可以包括构造成用于腔内部署的壳体，例如阴道内部分入人或动物受试者; 药物分配部分，其包含至少一种药物，所述药物分配部分构造成通过正位移从所述壳体分配药物; 以及渗透性增强剂分配部分，被配置为释放或产生渗透性增强物质，以在选择的时间在脉管内部署在人或动物受试者中的同时破坏邻近所述壳体的粘膜屏障的至少一个区域。 该装置可操作以将药物从壳体分配到由渗透性增强物质破坏的粘膜屏障的区域。
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