公开(公告)号：US08882748B2

公开(公告)日：2014-11-11

申请号：US12576087

申请日：2009-10-08

Applicant: Scott Uhland ,  Eric Peeters ,  Hussain Fatakdawala

Inventor： Scott Uhland ,  Eric Peeters ,  Hussain Fatakdawala

IPC: A61K9/22 ,  A61M31/00 ,  A61K9/00

CPC classification number: A61M31/002 ,  A61K9/0036

Abstract: Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.

Abstract translation: 提供了用于经粘膜药物递送的装置和方法。 透粘膜药物递送装置可以包括构造成用于腔内部署的壳体，例如阴道内部分入人或动物受试者; 药物分配部分，其包含至少一种药物，所述药物分配部分构造成通过正位移从所述壳体分配药物; 以及渗透性增强剂分配部分，被配置为释放或产生渗透性增强物质，以在选择的时间在脉管内部署在人或动物受试者中的同时破坏邻近所述壳体的粘膜屏障的至少一个区域。 该装置可操作以将药物从壳体分配到由渗透性增强物质破坏的粘膜屏障的区域。

公开(公告)号：US08672460B2

公开(公告)日：2014-03-18

申请号：US12712916

申请日：2010-02-25

Applicant: Armin R. Volkel ,  David Biegelsen ,  Philip D. Floyd ,  Greg Anderson ,  Fred Endicott ,  Eric Peeters ,  Jaan Noolandi ,  Karen A. Moffat ,  Peter M. Kazmaier ,  Maria McDougall ,  Daniel G. Bobrow

Inventor： Armin R. Volkel ,  David Biegelsen ,  Philip D. Floyd ,  Greg Anderson ,  Fred Endicott ,  Eric Peeters ,  Jaan Noolandi ,  Karen A. Moffat ,  Peter M. Kazmaier ,  Maria McDougall ,  Daniel G. Bobrow

IPC: B41J2/085

CPC classification number: B03C5/028

Abstract: Various particle transport systems and components for use in such systems are described. The systems utilize one or more traveling wave grids to selectively transport, distribute, separate, or mix different populations of particles. Numerous systems configured for use in two dimensional and three dimensional particle transport are described.

Abstract translation: 描述了用于这种系统的各种粒子输送系统和部件。 该系统利用一个或多个行波网来选择性地输送，分配，分离或混合不同粒子群。 描述了配置用于二维和三维粒子传输的许多系统。

公开(公告)号：US08561963B2

公开(公告)日：2013-10-22

申请号：US11959778

申请日：2007-12-19

Applicant: Ashish Pattekar ,  Eugene M Chow ,  Eric Peeters

Inventor： Ashish Pattekar ,  Eugene M Chow ,  Eric Peeters

IPC: F16K31/128

CPC classification number: F16K99/0001 ,  B01L3/502738 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/0887 ,  B01L2400/0655 ,  F16K99/0026 ,  Y10T137/0318 ,  Y10T137/0391 ,  Y10T137/87249

Abstract: An improved microvalve is described. The microvalve includes a corresponding actuation aperture in an actuation aperture layer. A control fluid flows through the actuation aperture. The flow of the control fluid is controlled by an electric field typically applied via a charge distribution near an actuation aperture layer. In one embodiment, the electric field may adjust the opening and closing of the actuation aperture thereby controlling the flow of the control fluid. In a second embodiment, the control fluid is an electrorheological fluid where the electric field controls the viscosity of the ER fluid thereby controlling fluid flow through the actuation aperture. In both embodiments the flow of the control fluid controls stretching of a flexible membrane formed along the wall of a conduit through which a fluid to be controlled flows. The stretching of the flexible membrane controlling the flow of the main fluid to be controlled.

Abstract translation: 描述了改进的微型阀。 微型阀包括致动孔层中相应的致动孔。 控制流体流过致动孔。 控制流体的流动由通常通过致动孔层附近的电荷分布施加的电场来控制。 在一个实施例中，电场可以调节致动孔的打开和关闭，从而控制控制流体的流动。 在第二实施例中，控制流体是电流变流体，其中电场控制ER流体的粘度，从而控制通过致动孔的流体流动。 在两个实施例中，控制流体的流动控制沿导管的壁形成的柔性膜的拉伸，待控制的流体通过该壁流动。 柔性膜的拉伸控制要控制的主流体的流动。

公开(公告)号：US08550604B2

公开(公告)日：2013-10-08

申请号：US12712897

申请日：2010-02-25

Applicant: Armin R. Volkel ,  David Biegelsen ,  Philip D. Floyd ,  Greg Anderson ,  Fred Endicott ,  Eric Peeters ,  Jaan Noolandi ,  Karen A. Moffat ,  Peter M. Kazmaier ,  Maria McDougall ,  Daniel G. Bobrow

Inventor： Armin R. Volkel ,  David Biegelsen ,  Philip D. Floyd ,  Greg Anderson ,  Fred Endicott ,  Eric Peeters ,  Jaan Noolandi ,  Karen A. Moffat ,  Peter M. Kazmaier ,  Maria McDougall ,  Daniel G. Bobrow

IPC: B41J2/175

CPC classification number: B03C5/028

Abstract: Various particle transport systems and components for use in such systems are described. The systems utilize one or more traveling wave grids to selectively transport, distribute, separate, or mix different populations of particles. Numerous systems configured for use in two dimensional and three dimensional particle transport are described.

公开(公告)号：US08388569B2

公开(公告)日：2013-03-05

申请号：US13089769

申请日：2011-04-19

Applicant: Scott Uhland ,  Eric Peeters

Inventor： Scott Uhland ,  Eric Peeters

IPC: A61M37/00

CPC classification number: A61M37/00 ,  A61D7/00 ,  A61M5/2046 ,  A61M5/2053 ,  A61M5/3007 ,  A61M5/3015

Abstract: Delivery devices, methods and systems are provided for the delivery of particles into a biological tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and adapted to form a collimated stream of the first plurality of particles entrained in the gas. The device also includes a tissue-interfacing surface adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the collimated stream of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue.

Abstract translation: 提供递送装置，方法和系统用于将颗粒递送到生物组织中。 该装置包括气体源，其包括气体或能选择性地产生气体; 包括第一多个颗粒的第一颗粒源; 第一准直器，其与气体源流体连接并且适于形成夹带在气体中的第一多个颗粒的准直流。 该装置还包括适于与组织的表面相接合并且使第一准直器与组织对准的组织接合表面，使得第一多个颗粒的准直流将沿基本上垂直于组织的表面的方向穿透组织 组织。

公开(公告)号：US20120285550A1

公开(公告)日：2012-11-15

申请号：US13557157

申请日：2012-07-24

Applicant: Ashish Pattekar ,  Eugene M. Chow ,  Eric Peeters

Inventor： Ashish Pattekar ,  Eugene M. Chow ,  Eric Peeters

IPC: F17D1/16

CPC classification number: F16K99/0001 ,  B01L3/502738 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/0887 ,  B01L2400/0655 ,  F16K99/0026 ,  Y10T137/0318 ,  Y10T137/0391 ,  Y10T137/87249

Abstract: A method of controlling a main fluid in a conduit using a microvalve is described. The microvalve includes a corresponding actuation aperture in an actuation aperture layer. A control fluid flows through the actuation aperture in response to an electric field applied via a charge distribution near an actuation aperture layer. In one embodiment, the electric field may adjust the opening and closing of the actuation aperture thereby controlling the flow of the control fluid. In a second embodiment, the control fluid is an electrorheological fluid where the electric field controls the viscosity of the ER fluid, thereby controlling fluid flow through the actuation aperture. In both embodiments the flow of the control fluid controls stretching of a flexible membrane into and out of the conduit, thereby controlling the flow of the main fluid by opening or closing the conduit.

Abstract translation: 描述了使用微型阀控制导管中的主流体的方法。 微型阀包括致动孔层中相应的致动孔。 响应于通过致动孔层附近的电荷分布施加的电场，控制流体流过致动孔。 在一个实施例中，电场可以调节致动孔的打开和关闭，从而控制控制流体的流动。 在第二实施例中，控制流体是电流变流体，其中电场控制ER流体的粘度，由此控制通过致动孔的流体流动。 在两个实施例中，控制流体的流动控制柔性膜进出导管的伸展，从而通过打开或关闭导管来控制主流体的流动。

公开(公告)号：US20120274914A1

公开(公告)日：2012-11-01

申请号：US13204567

申请日：2011-08-05

Applicant: Timothy Stowe ,  Eric Peeters

Inventor： Timothy Stowe ,  Eric Peeters

IPC: G03B27/42

CPC classification number: B41F7/24 ,  B41F7/00 ,  B41F7/025 ,  B41F7/26 ,  B41F31/302 ,  B41F35/02 ,  B41M1/06 ,  B41P2227/70

Abstract: A reimageable layer of an imaging member is provided with a dampening fluid layer. The reimageable layer has specific properties such as composition, surface profile, and so on so as to be well suited for receipt and carrying the dampening fluid layer. An optical patterning subsystem such as a scanned modulated laser patterns the dampening fluid layer. Ink having a first set of properties such as color, composition, etc., is applied at an inking subsystem such that it selectively resides in voids formed by the patterning subsystem in the dampening fluid layer to thereby form an inked latent image. The inked latent image is then transferred to a substrate, and the reimageable surface cleaned. The process is repeated for a second ink having properties different than the first. Each ink image may successively be applied to the substrate, or a composite image may be formed then applied to the substrate.

Abstract translation: 成像构件的可再成像层设置有阻尼流体层。 可再成像层具有特定的性质，例如组成，表面轮廓等，以便很好地适合接收和承载润版液层。 诸如扫描调制激光器的光学图案化子系统对阻尼流体层进行图案化。 具有第一组性质如颜色，组成等的油墨被施加在着墨子系统上，使得其选择性地驻留在阻尼流体层中由图案化子系统形成的空隙中，从而形成着墨潜影。 然后将着墨的潜像转印到基底上，并清洁可再成像的表面。 对于具有不同于第一墨水的性质的第二墨水重复该过程。 每个油墨图像可以连续地施加到基板上，或者可以形成合成图像然后施加到基板。

公开(公告)号：US20120271218A1

公开(公告)日：2012-10-25

申请号：US13089777

申请日：2011-04-19

Applicant: Scott Uhland ,  Eric Peeters

Inventor： Scott Uhland ,  Eric Peeters

IPC: A61M37/00

CPC classification number: A61K9/0021 ,  A61K9/0009 ,  A61M5/3015

Abstract: Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.

Abstract translation: 提供药物递送装置和方法用于将物质递送到人或动物组织中。 该装置包括气体源，其包括气体或能够选择性地产生气体。 该装置还包括定位并构造成将药物释放到气体中的药物源。 药物源包括其上设置有药物的可释放活化的带。 该装置还包括与气体源流体连接的第一准直仪。 具有入口端和出口端的第一准直器适于在气体中形成包含药物的准直气流。

公开(公告)号：US20120236098A1

公开(公告)日：2012-09-20

申请号：US13481645

申请日：2012-05-25

Applicant: Ashish Pattekar ,  Eric Peeters

Inventor： Ashish Pattekar ,  Eric Peeters

IPC: B41J2/01

CPC classification number: B41J2/0057

Abstract: An embodiment is a method and apparatus for thermal ink transfer. An endless belt having a thin thickness transfers ink from an ink donor roll to an image substrate based on a pattern on the belt. A heating unit heats the belt locally as needed in vicinity of contact between the belt and the ink donor roll.One disclosed feature of the embodiments is a method to transfer ink. An endless belt is driven to transfer ink from an ink donor roll to an image substrate based on a pattern of a fountain solution formed on the belt. The belt is heated locally as needed in vicinity of contact between the belt and the ink donor roll.

Abstract translation: 实施例是用于热墨转移的方法和装置。 具有薄的厚度的环形带基于带上的图案将油墨从供墨辊转印到图像基板。 加热单元根据需要在带和供墨辊之间的接触附近局部加热带。 实施例的一个公开的特征是转印墨水的方法。 基于形成在带上的润版液的图案，驱动环形带将油墨从供墨辊转印到图像基板。 带必须在带和供墨辊之间的接触附近被局部加热。

公开(公告)号：US20120103217A1

公开(公告)日：2012-05-03

申请号：US13095737

申请日：2011-04-27

Applicant: Timothy Stowe ,  Eric Peeters ,  Martin Sheridan ,  Ashish Pattekar ,  Gregory Anderson

Inventor： Timothy Stowe ,  Eric Peeters ,  Martin Sheridan ,  Ashish Pattekar ,  Gregory Anderson

IPC: B41F35/00

CPC classification number: B41F35/02 ,  B41C1/1033 ,  B41F7/00 ,  B41F31/002 ,  B41F31/005 ,  B41F31/02 ,  B41N1/003 ,  B41N1/12 ,  B41N1/22 ,  B41N3/006 ,  B41P2227/70 ,  B41P2235/21 ,  B41P2235/22 ,  B41P2235/23 ,  B41P2235/26 ,  B41P2235/50

Abstract: An cleaning subsystem for a variable data lithography system includes a first cleaning member having a conformable adhesive surface disposed for physical contact with an imaging member such that residual ink remaining on the imaging member, such as following transfer of an inked latent image from the imaging member to a substrate, adheres to the conformable adhesive surface and is thereby removed from the imaging member. The cleaning subsystem may further include a second cleaning member, in physical contact with the first cleaning member, having a relatively hard, smooth surface such that residual ink removed from the imaging member and adhering to the adhesive surface of the first cleaning member may split onto the second cleaning member.

Abstract translation: 用于可变数据光刻系统的清洁子系统包括第一清洁构件，其具有被设置用于与成像构件物理接触的适形粘合剂表面，使得残留在成像构件上的残留墨水，例如从成像构件转移墨水潜像 粘合到基底上，粘附到适形的粘合剂表面上，从而从成像构件上除去。 清洁子系统还可以包括与第一清洁构件物理接触的第二清洁构件，具有相对硬的光滑的表面，使得从成像构件移除并附着到第一清洁构件的粘合表面上的残余墨可分裂成 第二清洁构件。