发明申请
US20050123505A1 Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition
有权
可生物降解的透明质酸衍生物和可生物降解的聚合胶束组合物
- 专利标题： Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition
- 专利标题（中）： 可生物降解的透明质酸衍生物和可生物降解的聚合胶束组合物
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申请号： US10992387申请日： 2004-11-18
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公开(公告)号： US20050123505A1公开(公告)日： 2005-06-09
- 发明人: Jui-Hsiang Chen , Bin-Hong Tsai , Hsuen-Tseng Chang , Muh-Lan Chen , Yu-Hua Chen , Shu-Hua Jan , Mei-Jung Liu
- 申请人： Jui-Hsiang Chen , Bin-Hong Tsai , Hsuen-Tseng Chang , Muh-Lan Chen , Yu-Hua Chen , Shu-Hua Jan , Mei-Jung Liu
- 优先权： GB0328168.0 20031204
- 主分类号： A61K47/36
- IPC分类号： A61K47/36 ; A61K47/48 ; C08B37/08 ; A61K31/728 ; A61K9/14
摘要：
A biodegradable hyaluronic acid derivative comprising a modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C═O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group or a prepolymer, and p is an integer of 1 to 4. The biodegradable hyaluronic acid derivative when dissolved in a hydrophilic medium can form micelles and can be used to entrap a pharmaceutically active or bioactive molecule.
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