发明申请
US20050129610A1 Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor
审中-公开
成像剂和α7-烟碱型胆碱能受体成像方法
- 专利标题： Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor
- 专利标题（中）： 成像剂和α7-烟碱型胆碱能受体成像方法
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申请号： US10877813申请日： 2004-06-24
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公开(公告)号： US20050129610A1公开(公告)日： 2005-06-16
- 发明人: Martin Pomper , John Musachio , Hong Fan , Robert Dannals , Catherine Foss , Eifion Phillips , John Gordon , Dennis McCarthy , Richard Keith , Mark Smith , Richard Heys , Peter Dorff
- 申请人： Martin Pomper , John Musachio , Hong Fan , Robert Dannals , Catherine Foss , Eifion Phillips , John Gordon , Dennis McCarthy , Richard Keith , Mark Smith , Richard Heys , Peter Dorff
- 专利权人： Johns Hopkins University
- 当前专利权人： Johns Hopkins University
- 主分类号： A61K
- IPC分类号： A61K20060101 ; A61K31/4747 ; A61K51/00 ; C07D453/02 ; C07D491/107 ; C07D491/14 ; C07D491/22 ; C07F5/00
摘要：
The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the a7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express a7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.
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