发明申请
US20050129693A1 Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
审中-公开
用于治疗败血性休克，恶病质，免疫疾病和皮肤病症的干扰素-γ结合分子
- 专利标题： Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
- 专利标题（中）： 用于治疗败血性休克，恶病质，免疫疾病和皮肤病症的干扰素-γ结合分子
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申请号： US10985581申请日： 2004-11-10
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公开(公告)号： US20050129693A1公开(公告)日： 2005-06-16
- 发明人: Marie-Ange Buyse , Erwin Sablon
- 申请人： Marie-Ange Buyse , Erwin Sablon
- 专利权人： INNOGENETICS N.V.
- 当前专利权人： INNOGENETICS N.V.
- 优先权： EP97870122.5 19970818; EP98870139.7 19980618
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/00 ; C07K16/00 ; C07K16/24 ; C07K16/46 ; A61K39/395
摘要：
The present invention concerns molecules which bind and neutralize the cytokine interferon-gamma. More specifically, the present invention relates to sheep-derived antibodies and engineered antibody constructs, such as humanized single-chain Fv fragments, chimeric antibodies, diabodies, triabodies, tetravalent antibodies, peptabodies and hexabodies which can be used to treat diseases wherein interferon-gamma activity is pathogenic. Examples of such diseases are: septic shock, cachexia, multiple sclerosis and psoriasis.
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