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    Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
    1.
    发明申请
    Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders 审中-公开
    用于治疗败血性休克，恶病质，免疫疾病和皮肤病症的干扰素-γ结合分子

    公开(公告)号：US20050129693A1

    公开(公告)日：2005-06-16

    申请号：US10985581

    申请日：2004-11-10

    申请人： Marie-Ange Buyse ,  Erwin Sablon

    发明人： Marie-Ange Buyse ,  Erwin Sablon

    IPC分类号： A61K38/00 ,  C07K14/00 ,  C07K16/00 ,  C07K16/24 ,  C07K16/46 ,  A61K39/395

    CPC分类号： C07K16/00 ,  A61K38/00 ,  C07K16/249 ,  C07K16/468 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention concerns molecules which bind and neutralize the cytokine interferon-gamma. More specifically, the present invention relates to sheep-derived antibodies and engineered antibody constructs, such as humanized single-chain Fv fragments, chimeric antibodies, diabodies, triabodies, tetravalent antibodies, peptabodies and hexabodies which can be used to treat diseases wherein interferon-gamma activity is pathogenic. Examples of such diseases are: septic shock, cachexia, multiple sclerosis and psoriasis.

    摘要翻译： 本发明涉及结合和中和细胞因子干扰素-γ的分子。 更具体地，本发明涉及可以用于治疗其中干扰素-γ的疾病的绵羊衍生的抗体和工程改造的抗体构建体，例如人源化单链Fv片段，嵌合抗体，双抗体，三抗体，四价抗体，肽抗体和六抗体 活动是致病的。 这些疾病的例子有：败血性休克，恶病质，多发性硬化和牛皮癣。

    Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
    2.
    发明授权
    Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders 失效
    用于治疗败血性休克，恶病质，免疫疾病和皮肤病症的干扰素-γ结合分子

    公开(公告)号：US06350860B1

    公开(公告)日：2002-02-26

    申请号：US09485737

    申请日：2000-02-14

    申请人： Marie-Ange Buyse ,  Erwin Sablon

    发明人： Marie-Ange Buyse ,  Erwin Sablon

    IPC分类号： C07K1624

    CPC分类号： C07K16/00 ,  A61K38/00 ,  C07K16/249 ,  C07K16/468 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention concerns molecules which bind and neutralize the cytokine interferon-gamma. More specifically, the present invention relates to sheep-derived antibodies and engineered antibody constructs, such as humanized single-chain Fv fragments, chimeric antibodies, diabodies, triabodies, tetravalent antibodies, peptabodies and hexabodies which can be used to treat diseases wherein interferon-gamma activity is pathogenic. Examples of such diseases are: septic shock, cachexia, multiple sclerosis and psoriasis.

    摘要翻译： 本发明涉及结合和中和细胞因子干扰素-γ的分子。 更具体地，本发明涉及可以用于治疗其中干扰素-γ的疾病的绵羊衍生的抗体和工程改造的抗体构建体，例如人源化单链Fv片段，嵌合抗体，双抗体，三抗体，四价抗体，肽抗体和六抗体 活动是致病的。 这些疾病的例子有：败血性休克，恶病质，多发性硬化和牛皮癣。

    Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
    3.
    发明授权
    Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders 失效
    用于治疗败血性休克，恶病质，免疫疾病和皮肤病症的干扰素-γ结合分子

    公开(公告)号：US06830752B2

    公开(公告)日：2004-12-14

    申请号：US10071485

    申请日：2002-02-07

    申请人： Marie-Ange Buyse ,  Erwin Sablon

    发明人： Marie-Ange Buyse ,  Erwin Sablon

    IPC分类号： A61K39395

    CPC分类号： C07K16/00 ,  A61K38/00 ,  C07K16/249 ,  C07K16/468 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention concerns molecules which bind and neutralize the cytokine interferon-gamma. More specifically, the present invention relates to sheep-derived antibodies and engineered antibody constructs, such as humanized single-chain Fv fragments, chimeric antibodies, diabodies, triabodies, tetravalent antibodies, peptabodies and hexabodies which can be used to treat diseases wherein interferon-gamma activity is pathogenic. Examples of such diseases are: septic shock, cachexia, multiple sclerosis and psoriasis.

    摘要翻译： 本发明涉及结合和中和细胞因子干扰素-γ的分子。 更具体地，本发明涉及可以用于治疗其中干扰素-γ的疾病的绵羊衍生的抗体和工程改造的抗体构建体，例如人源化单链Fv片段，嵌合抗体，双抗体，三抗体，四价抗体，肽抗体和六抗体 活动是致病的。 这些疾病的例子有：败血性休克，恶病质，多发性硬化和牛皮癣。

    TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    4.
    发明申请
    TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
    涉及免疫球蛋白单个可变区域的测定中预测，检测和降低相关蛋白质干扰的技术

    公开(公告)号：US20140199295A1

    公开(公告)日：2014-07-17

    申请号：US14128681

    申请日：2012-06-25

    申请人： Judith Baumeister ,  Marie-Paule Lucienne Armanda Bouche ,  Carlo Boutton ,  Marie-Ange Buyse ,  Veerle Snoeck ,  Stephanie Staelens

    发明人： Judith Baumeister ,  Marie-Paule Lucienne Armanda Bouche ,  Carlo Boutton ,  Marie-Ange Buyse ,  Veerle Snoeck ,  Stephanie Staelens

    IPC分类号： C07K16/00

    CPC分类号： C07K16/28 ,  C07K16/00 ,  C07K16/4283 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2317/94 ,  C07K2319/30 ,  G01N33/6854

    摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

    摘要翻译： 本发明提供并且在某些特定但非限制性方面涉及：可用于预测给定ISV是否将如本文所述受到蛋白质干扰和/或产生（特异性）信号的测定法 测定（例如在ADA免疫测定中）。 这样的预测测定可以例如用于测试给定的ISV是否可能具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不是或不太容易发生蛋白质干扰的ISV或给出这样的信号; 作为可用于测试对ISV的某些修改（完全或部分）是否降低其引起这种干扰或这种信号的趋势的测定或测试; 和/或作为可用于指导ISV的修饰或改进的测定或测试，以便减少引起这种蛋白质干扰或信号的趋势; - 用于修饰和/或改善ISV的方法以消除或减少其引起这种蛋白质干扰或这种信号的倾向; - 可以引入到ISV中的改变，其去除或减少其引起这种蛋白质干扰或这种信号的趋势; 已经特别选择的ISV（例如，使用本文所述的测定）具有没有或低（呃）/降低的趋势导致这种蛋白质干扰或这种信号; 修饰和/或改进的ISV，其没有或低（呃）/降低的趋势引起这种蛋白质干扰或这种信号。

    Method for simultaneous detection of HIV antigens and HIV antibodies
    7.
    发明授权
    Method for simultaneous detection of HIV antigens and HIV antibodies 有权
    同时检测HIV抗原和HIV抗体的方法

    公开(公告)号：US06593079B1

    公开(公告)日：2003-07-15

    申请号：US09381009

    申请日：2000-01-12

    申请人： Frederic Donie ,  Elke Faatz ,  Barbara Upmeier ,  Eva Hoess ,  Marie-Ange Buyse ,  Eric Saman

    发明人： Frederic Donie ,  Elke Faatz ,  Barbara Upmeier ,  Eva Hoess ,  Marie-Ange Buyse ,  Eric Saman

    IPC分类号： C12Q106

    CPC分类号： G01N33/56988 ,  C07K16/1054

    摘要： The invention concerns a process for diagnosis of an HIV infection by means of an immunoassay using the specific detection of the p24 antigen of HIV1, HIV1-Sub0 and/or the p26 antigen of HIV2, at least one antibody against the env region of HIV1, HIV1-Sub0 and/or of HIV2 and at least one antibody against the pol and/or gag region of HIV1, HIV1-Sub0 and/or HIV2, reagent kits and test strips suitable for diagnostic procedure as well as monoclonal antibodies against p24 and their use.

    摘要翻译： 本发明涉及通过免疫测定来诊断HIV感染的方法，其使用HIV2的HIV1，HIV1-Sub0和/或p26抗原的p24抗原的特异性检测，至少一种针对HIV1的env区域的抗体， HIV1-Sub0和/或HIV2的抗体和抗HIV1，HIV1-Sub0和/或HIV2的pol和/或gag区域的至少一种抗体，适用于诊断程序的试剂盒和测试条以及针对p24的单克隆抗体及其 使用。