发明申请
- 专利标题： Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity
- 专利标题（中）： 具有细胞毒性抑制活性的肽和筛选具有细胞毒性抑制活性的肽的方法
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申请号： US10477101申请日： 2002-05-10
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公开(公告)号： US20050143311A1公开(公告)日： 2005-06-30
- 发明人: Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
- 申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
- 优先权： JP2001-141466 20010511
- 国际申请： PCT/JP02/04557 WO 20020510
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; G01N33/50 ; A61K38/08 ; C07K7/08
摘要：
A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
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