发明申请
- 专利标题： Dna enzyme to inhibit plasminogen activator inhibitor-1
- 专利标题（中）： Dna酶抑制纤溶酶原激活物抑制剂-1
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申请号： US10512496申请日： 2003-04-23
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公开(公告)号： US20050148527A1公开(公告)日： 2005-07-07
- 发明人: Silviu Itescu
- 申请人： Silviu Itescu
- 优先权： US10/128706 20020423
- 国际申请： PCT/US03/12767 WO 20030423
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/122 ; A61K31/37 ; A61K31/616 ; A61K31/7088 ; A61K31/727 ; A61K38/00 ; A61K38/22 ; A61K38/46 ; A61K39/395 ; A61K45/00 ; A61K48/00 ; A61P7/04 ; A61P9/00 ; A61P9/02 ; A61P9/10 ; A61P11/00 ; A61P13/12 ; A61P17/00 ; A61P27/02 ; A61P29/00 ; C07H21/02 ; C07K14/81 ; C12N20060101 ; C12N15/113 ; C12Q1/68
摘要：
The present invention provides DNAzymes and ribozymes that specifically cleave PAI-1-encoding mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of PAI-1-encoding mRNA. The invention also provides various methods of inhibiting the expression of PAI-1, and methods of treating diseases by such. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes, antisense oligonucleotides, or other inhibitors of PAI-1 expression as active ingredients.
公开/授权文献
- US07662794B2 DNA enzyme to inhibit plasminogen activator inhibitor-1 公开/授权日：2010-02-16
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