Methods for treating obesity and/or metabolic syndrome
    3.
    发明授权
    Methods for treating obesity and/or metabolic syndrome 有权
    治疗肥胖症和/或代谢综合征的方法

    公开(公告)号:US09388385B2

    公开(公告)日:2016-07-12

    申请号:US14118862

    申请日:2012-05-18

    IPC分类号: C12N5/0775 A61K35/28

    CPC分类号: A61K35/28 C12N5/0663

    摘要: The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.

    摘要翻译: 本公开提供了治疗或预防肥胖症或引起体重减轻或治疗或预防代谢综合征的方法,其包括向受试者施用富含STRO-1 +细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。

    Methods of treating or preventing rheumatic disease
    5.
    发明授权
    Methods of treating or preventing rheumatic disease 有权
    治疗或预防风湿病的方法

    公开(公告)号:US09265796B2

    公开(公告)日:2016-02-23

    申请号:US14130647

    申请日:2012-07-04

    CPC分类号: A61K35/28 C12N5/0663

    摘要: The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.

    摘要翻译: 本公开提供了治疗或预防风湿性疾病的方法,其包括给予富含STRO-1 +细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。

    Method for treating or preventing a pancreatic dysfunction
    7.
    发明授权
    Method for treating or preventing a pancreatic dysfunction 有权
    治疗或预防胰腺功能障碍的方法

    公开(公告)号:US08894972B2

    公开(公告)日:2014-11-25

    申请号:US13129180

    申请日:2009-11-19

    IPC分类号: A61K49/00 C12N5/071 A61K35/12

    摘要: The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1+ cells and/or progeny cells thereof and/or soluble factors derived therefrom. The method of the invention is useful for treating and/or preventing and/or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.

    摘要翻译: 本发明提供了一种在有需要的受试者中改善胰腺功能的方法,所述方法包括给予受试者STRO-1 +细胞和/或其后代细胞和/或由其衍生的可溶性因子。 本发明的方法可用于治疗和/或预防和/或延缓由胰腺功能障碍引起或与胰腺功能障碍相关的疾病的发作或进展,例如由胰腺的内分泌或外分泌功能异常引起。

    Regeneration of endogenous myocardial tissue
    8.
    发明授权
    Regeneration of endogenous myocardial tissue 有权
    内源性心肌组织再生

    公开(公告)号:US08663652B2

    公开(公告)日:2014-03-04

    申请号:US10693480

    申请日:2003-10-23

    申请人: Silviu Itescu

    发明人: Silviu Itescu

    摘要: This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject a composition comprising an amount of a human stromal derived factor-1 and an amount of a human granulocyte-colony stimulating factor, the composition being administered in an amount effective to cause proliferation of cardiomyocytes within the subject's heart so as to thereby treat the disorder. This invention also provides a method of treating a subject suffering from a disorder of a tissue involving loss and/or apoptosis of cells of the tissue which comprises administering to the subject a composition comprising an amount of an agent which induces phosphorylation and/or activation of protein kinase B, or an agent which induces phosphorylation and/or activation of an extracellular signal-regulated protein kinase, or an agent which induces activation of CXCR4.

    摘要翻译: 本发明提供一种治疗受试者心脏疾病涉及心肌细胞损失的方法,其包括向受试者施用包含一定量的人基质衍生因子-1和一定量的人粒细胞集落刺激因子的组合物,所述组合物 以有效引起受试者心脏内的心肌细胞增殖的量施用,从而治疗该病症。 本发明还提供了一种治疗患有组织疾病的组织损伤和/或凋亡的受试者的方法,其包括向受试者施用包含一定量的诱导磷酸化和/或激活的药物的组合物 蛋白激酶B或诱导细胞外信号调节蛋白激酶的磷酸化和/或激活的药剂或诱导CXCR4激活的药剂。