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公开(公告)号:US20170274016A1
公开(公告)日:2017-09-28
申请号:US15485637
申请日:2017-04-12
申请人: Silviu Itescu , Ravi Krishnan
发明人: Silviu Itescu , Ravi Krishnan
IPC分类号: A61K35/28 , C12N5/0775
CPC分类号: A61K35/28 , A61K38/39 , A61K2035/124 , A61P19/08 , A61P19/10 , C12N5/0663 , A61K2300/00
摘要: The present disclosure provides methods of increasing osteoblastic function in a subject, the method comprising systemically administering to the subject a population of stem cells and/or progeny thereof and/or soluble factors derived therefrom.
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公开(公告)号:US09642878B2
公开(公告)日:2017-05-09
申请号:US14343730
申请日:2012-09-07
申请人: Silviu Itescu , Ravi Krishnan
发明人: Silviu Itescu , Ravi Krishnan
IPC分类号: A61K35/28 , C12N5/0775 , A61K35/12
CPC分类号: A61K35/28 , A61K38/39 , A61K2035/124 , A61P19/08 , A61P19/10 , C12N5/0663 , A61K2300/00
摘要: The present disclosure provides methods of increasing osteoblastic function in a subject, the method comprising systemically administering to the subject a population of stem cells and/or progeny thereof and/or soluble factors derived therefrom.
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公开(公告)号:US09388385B2
公开(公告)日:2016-07-12
申请号:US14118862
申请日:2012-05-18
申请人: Ravi Krishnan , Silviu Itescu
发明人: Ravi Krishnan , Silviu Itescu
IPC分类号: C12N5/0775 , A61K35/28
CPC分类号: A61K35/28 , C12N5/0663
摘要: The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
摘要翻译: 本公开提供了治疗或预防肥胖症或引起体重减轻或治疗或预防代谢综合征的方法,其包括向受试者施用富含STRO-1 +细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。
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公开(公告)号:US20160361363A1
公开(公告)日:2016-12-15
申请号:US15055221
申请日:2016-02-26
CPC分类号: A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
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公开(公告)号:US09265796B2
公开(公告)日:2016-02-23
申请号:US14130647
申请日:2012-07-04
申请人: Peter Ghosh , Silviu Itescu
发明人: Peter Ghosh , Silviu Itescu
IPC分类号: A01N63/00 , A61K35/28 , C12N5/0775
CPC分类号: A61K35/28 , C12N5/0663
摘要: The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
摘要翻译: 本公开提供了治疗或预防风湿性疾病的方法,其包括给予富含STRO-1 +细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。
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公开(公告)号:US20150150943A1
公开(公告)日:2015-06-04
申请号:US13938608
申请日:2013-07-10
申请人: Silviu Itescu
发明人: Silviu Itescu
CPC分类号: A61K38/195 , A61K35/44 , A61K38/193 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K16/2866 , C12N5/0692 , C12N2501/21
摘要: A method is provided for increasing trafficking of endothelial progenitor cells to an ischemic myocardium in a subject's heart comprising administering to the subject's heart an amount of Stromal-Derived Factor-1 (SDF-1).
摘要翻译: 提供了一种用于增加受试者心脏中内皮祖细胞向缺血心肌的运送的方法,其包括向受试者的心脏施用一定量的基质衍生因子-1(SDF-1)。
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公开(公告)号:US08894972B2
公开(公告)日:2014-11-25
申请号:US13129180
申请日:2009-11-19
申请人: Silviu Itescu , Ravi Krishnan
发明人: Silviu Itescu , Ravi Krishnan
CPC分类号: A61K35/545 , A61K35/12 , A61K45/06 , C12N5/0676 , G01N33/66 , G01N33/6893 , G01N33/74 , G01N2333/47 , G01N2333/62 , G01N2800/042
摘要: The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1+ cells and/or progeny cells thereof and/or soluble factors derived therefrom. The method of the invention is useful for treating and/or preventing and/or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.
摘要翻译: 本发明提供了一种在有需要的受试者中改善胰腺功能的方法,所述方法包括给予受试者STRO-1 +细胞和/或其后代细胞和/或由其衍生的可溶性因子。 本发明的方法可用于治疗和/或预防和/或延缓由胰腺功能障碍引起或与胰腺功能障碍相关的疾病的发作或进展,例如由胰腺的内分泌或外分泌功能异常引起。
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公开(公告)号:US08663652B2
公开(公告)日:2014-03-04
申请号:US10693480
申请日:2003-10-23
申请人: Silviu Itescu
发明人: Silviu Itescu
IPC分类号: A61K38/16 , A61K38/18 , C07K14/475
CPC分类号: A61K38/193 , A61K31/085 , A61K31/506 , A61K31/7105 , A61K31/711 , A61K35/34 , A61K35/44 , A61K38/1709 , A61K38/1825 , A61K38/1866 , A61K38/1891 , A61K38/195 , A61K38/2053 , A61K45/06 , A61K2039/505 , C07K16/2866 , C07K2317/76 , C12N5/069 , C12N15/113 , C12N15/1137 , G01N2510/00 , A61K2300/00
摘要: This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject a composition comprising an amount of a human stromal derived factor-1 and an amount of a human granulocyte-colony stimulating factor, the composition being administered in an amount effective to cause proliferation of cardiomyocytes within the subject's heart so as to thereby treat the disorder. This invention also provides a method of treating a subject suffering from a disorder of a tissue involving loss and/or apoptosis of cells of the tissue which comprises administering to the subject a composition comprising an amount of an agent which induces phosphorylation and/or activation of protein kinase B, or an agent which induces phosphorylation and/or activation of an extracellular signal-regulated protein kinase, or an agent which induces activation of CXCR4.
摘要翻译: 本发明提供一种治疗受试者心脏疾病涉及心肌细胞损失的方法,其包括向受试者施用包含一定量的人基质衍生因子-1和一定量的人粒细胞集落刺激因子的组合物,所述组合物 以有效引起受试者心脏内的心肌细胞增殖的量施用,从而治疗该病症。 本发明还提供了一种治疗患有组织疾病的组织损伤和/或凋亡的受试者的方法,其包括向受试者施用包含一定量的诱导磷酸化和/或激活的药物的组合物 蛋白激酶B或诱导细胞外信号调节蛋白激酶的磷酸化和/或激活的药剂或诱导CXCR4激活的药剂。
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公开(公告)号:US20130171113A1
公开(公告)日:2013-07-04
申请号:US13808093
申请日:2011-07-04
IPC分类号: A61K35/28
CPC分类号: A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
摘要翻译: 一种用于预防哺乳动物患者的GvHD并发症的发展或治疗的方法,其包括向所述哺乳动物施用富含STRO-1bright细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。
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公开(公告)号:US20130171099A1
公开(公告)日:2013-07-04
申请号:US13808092
申请日:2011-07-04
CPC分类号: A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要: A method for suppressing T cell activation which comprises contacting a cell population comprising T cells in vitro or ex viva with an effective amount of STRO-1+ cells and/or soluble factors derived therefrom to suppress cell activation.
摘要翻译: 一种抑制T细胞活化的方法,其包括使包含T细胞的细胞群体与有效量的STRO-1 +细胞和/或从其衍生的可溶性因子接触以抑制细胞活化。
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