发明申请
US20050163769A1 Chimeric and humanized antibodies to alpha5beta1 integrin that modulate angiogenesis
有权
调节血管发生的α5β1整联蛋白的嵌合和人源化抗体
- 专利标题： Chimeric and humanized antibodies to alpha5beta1 integrin that modulate angiogenesis
- 专利标题（中）： 调节血管发生的α5β1整联蛋白的嵌合和人源化抗体
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申请号： US10830956申请日： 2004-04-23
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公开(公告)号： US20050163769A1公开(公告)日： 2005-07-28
- 发明人: Vanitha Ramakrishnan , David Powers , Dale Johnson , Ursula Jeffry
- 申请人： Vanitha Ramakrishnan , David Powers , Dale Johnson , Ursula Jeffry
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/44 ; A61K39/395
摘要：
The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
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