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公开(公告)号：US20110038864A1
公开(公告)日：2011-02-17
申请号：US12892725
申请日：2010-09-28
申请人： Vinay BHASKAR , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
发明人： Vinay BHASKAR , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
IPC分类号： A61K39/395 , C07K16/22 , A61P35/00
CPC分类号： C07K16/3069 , A61K47/6817 , A61K47/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/77
摘要： Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
摘要翻译： 本文描述了可用于诊断和治疗癌症的方法和组合物。
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公开(公告)号：US20080044840A1
公开(公告)日：2008-02-21
申请号：US11837333
申请日：2007-08-10
申请人： Vinay BHASKAR , Agustin DE LA CALLE , Debbie LAW , Ingrid CARAS , Vanitha RAMAKRISHNAN , Richard MURRAY , Daniel AFAR , David POWERS
发明人： Vinay BHASKAR , Agustin DE LA CALLE , Debbie LAW , Ingrid CARAS , Vanitha RAMAKRISHNAN , Richard MURRAY , Daniel AFAR , David POWERS
IPC分类号： G01N33/574
CPC分类号： C07K16/3069 , A61K47/6817 , A61K47/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/77
摘要： Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
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公开(公告)号：US07285268B2
公开(公告)日：2007-10-23
申请号：US10830956
申请日：2004-04-23
CPC分类号： C07K16/4258 , A61K2039/505 , C07K16/2842 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
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公开(公告)号：US07060271B2
公开(公告)日：2006-06-13
申请号：US09003810
申请日：1998-01-07
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/71 , A61K38/00 , C07K16/2863 , C07K2317/34
摘要： The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
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公开(公告)号：US20060008415A1
公开(公告)日：2006-01-12
申请号：US11166906
申请日：2005-06-24
申请人： Elisabet Kaisheva , Supriya Gupta , Weichang Zhou , Robert Weinkam , Patrick Powers , Naichi Liu , Vanitha Ramakrishnan
发明人： Elisabet Kaisheva , Supriya Gupta , Weichang Zhou , Robert Weinkam , Patrick Powers , Naichi Liu , Vanitha Ramakrishnan
IPC分类号： A61K51/00 , A61K39/395
CPC分类号： A61K47/545 , A61K47/542
摘要： The present invention is directed to stable protein derivatives, e.g., antibodies, antibody fragments or peptides, with at least one free thiol group coupled to N-acetyl-L-cysteine, N-ethyl-maleimide, or cysteine and the methods of making such derivatives. In addition, stable liquid pharmaceutical formulations comprising such proteins or their derivatives and stable lyophilized pharmaceutical formulations comprising such proteins are provided. The present invention is also directed to a method of making a stable Fab′ fragment of an antibody and a method of controlling vascularization in injured or cancerous tissue comprising applying to the injured tissue one or more doses of the pharmaceutical formulations.
摘要翻译： 本发明涉及具有与N-乙酰基-L-半胱氨酸，N-乙基 - 马来酰亚胺或半胱氨酸偶联的至少一个游离巯基的稳定的蛋白质衍生物，例如抗体，抗体片段或肽，以及制备其的方法 衍生品 此外，提供包含这些蛋白质或其衍生物的稳定的液体药物制剂和包含这种蛋白质的稳定的冻干药物制剂。 本发明还涉及制备抗体的稳定Fab'片段的方法和控制受损组织或癌组织中的血管形成的方法，包括向损伤组织施用一个或多个剂量的药物制剂。
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公开(公告)号：US06953874B2
公开(公告)日：2005-10-11
申请号：US09775803
申请日：2001-02-05
IPC分类号： A01K67/027 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/02 , G01N33/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0381 , C07K14/705
摘要： The present invention relates to nonhuman transgenic animals in which the GP V gene has been modified. The invention is also useful for identifying agents that modulate the biological functions of GP V, including the screening and identification of potential therapeutic agents.
摘要翻译： 本发明涉及其中GPV基因已被修饰的非人类转基因动物。 本发明还可用于鉴定调节GPV的生物学功能的试剂，包括筛选和鉴定潜在的治疗剂。
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公开(公告)号：US06762029B2
公开(公告)日：2004-07-13
申请号：US09745842
申请日：2000-12-26
申请人： Pamela B. Conley , Hans-Michael Jantzen , Vanitha Ramakrishnan-DuBridge , David Jay Julius , Gunther Hollopeter
发明人： Pamela B. Conley , Hans-Michael Jantzen , Vanitha Ramakrishnan-DuBridge , David Jay Julius , Gunther Hollopeter
IPC分类号： G01N3353
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/705 , C07K16/28 , G01N33/502 , G01N33/5091 , G01N33/74 , G01N2333/726 , G01N2500/02
摘要： The present invention includes a novel subtype of the P2-purinergic receptor, referred to as the P2Y12 receptor. This receptor is expressed selectively in the platelets and brain, and couples to a pertussis toxin-sensitive G protein (Gi). Nucleic acids encoding the receptor and associated screening and therapeutic methods are also disclosed.
摘要翻译： 本发明包括称为P2Y12受体的P2-嘌呤能受体的新亚型。 该受体在血小板和脑中有选择性表达，并且与百日咳毒素敏感的G蛋白（Gi）偶联。 还公开了编码受体的核酸和相关筛选和治疗方法。
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8.发明申请CHIMERIC AND HUMANIZED ANTIBODIES TO ALPHA5BETA1 INTEGRIN THAT MODULATE ANGIOGENESIS 有权对调节血管生成的ALPHA5BETA1整合的重组和人类抗体公开(公告)号：US20110300133A1
公开(公告)日：2011-12-08
申请号：US13009757
申请日：2011-01-19
IPC分类号： A61K39/395 , A61P27/02 , C07K16/28
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/24
摘要： The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
摘要翻译： 本发明提供特异性识别α5和bgr1整联蛋白的嵌合和人源化抗体，以及使用抗体减少或抑制组织中血管发生的方法。 还提供了确定抗体的治疗可接受剂量的方法和包括其的药物组合物。
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公开(公告)号：US07879987B2
公开(公告)日：2011-02-01
申请号：US11840854
申请日：2007-08-17
IPC分类号： C07H21/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/24
摘要： The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
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公开(公告)号：US20080026033A1
公开(公告)日：2008-01-31
申请号：US11840871
申请日：2007-08-17
IPC分类号： A61K39/395 , A61P27/02 , C12N5/06 , C12N5/08
CPC分类号： C07K16/4258 , A61K2039/505 , C07K16/2842 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
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