发明申请
- 专利标题: Method for the production of chiral imidazolidin-2-ones
- 专利标题(中): 制备手性咪唑烷-2-酮的方法
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申请号: US10510439申请日: 2003-04-08
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公开(公告)号: US20050165078A1公开(公告)日: 2005-07-28
- 发明人: Hansgeorg Ernst , Jurgen Koppenhofer , Daniela Klein
- 申请人: Hansgeorg Ernst , Jurgen Koppenhofer , Daniela Klein
- 优先权: DE102158452 20020411
- 国际申请: PCT/EP03/03615 WO 20030408
- 主分类号: C07D233/34
- IPC分类号: C07D233/34 ; C07B53/00 ; C07B61/00 ; C07D233/00 ; A61K31/4178 ; A61K31/4168 ; C07D233/04 ; C07D47/02
摘要:
The invention relates to a process for preparing chiral imidazolidin-2-ones of the formula I in which R1 is C1-C8-alkyl, cyclohexyl, phenyl, a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto- or CF3-substituted phenyl radical, naphthyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy- or CF3-substituted naphthyl radical, R2 is C1-C8-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a phenyl-C1-C6-alkyl radical which may be substituted by a nitro, C1-C6-alkoxy, methylenedioxy or CF3 radical, and R3 is C1-C12-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, methylenedioxy-, dialkylamino- or CF3-substituted phenyl radical, by reacting a compound of the formula II or the salt thereof in which R1, R2 and R3 have the abovementioned meaning, with urea in the presence of an involatile ammonium salt, wherein the reaction is carried out in the presence of an aprotic polar organic solvent.
公开/授权文献
- US07365210B2 Method for the production of chiral imidazolidin-2-ones 公开/授权日:2008-04-29