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    Catalytic hydrogenation of ene-carbamates
    3.
    发明授权
    Catalytic hydrogenation of ene-carbamates 有权
    氨基甲酸酯的催化氢化

    公开(公告)号：US08546571B2

    公开(公告)日：2013-10-01

    申请号：US12518416

    申请日：2007-12-12

    申请人： David Alexander Learmonth ,  Antonio Zanotti-Gerosa ,  Gabriela Alexandra Grasa ,  Alexander Beliaev

    发明人： David Alexander Learmonth ,  Antonio Zanotti-Gerosa ,  Gabriela Alexandra Grasa ,  Alexander Beliaev

    IPC分类号： C07F9/00 ,  C07F9/50 ,  C07D233/00 ,  C07D233/04 ,  C07D311/00 ,  C07D311/04

    CPC分类号： C07D311/58

    摘要： A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral catalyst and a source of hydrogen, wherein: X is CH2, oxygen or sulphur; R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R4 is alkyl or aryl, wherein: the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means a phenyl or naphthyl group, optionally substituted by alkyloxy, halogen or nitro group; and the term halogen means fluorine, chlorine, bromine or iodine.

    摘要翻译： 一种制备式A化合物的S或R对映异构体的方法，该方法包括在手性催化剂和氢源存在下使式B化合物进行不对称氢化，其中：X为CH 2，氧或硫 ; R1，R2和R3相同或不同，表示氢，卤素，烷基，烷氧基，羟基，硝基，烷基羰基氨基，烷基氨基或二烷基氨基; 并且R 4是烷基或芳基，其中：术语烷基是指含有1-6个碳原子的直链或支链的烃链，任选地被芳基，烷氧基，卤素，烷氧基羰基或羟基羰基取代; 术语芳基是指任选被烷氧基，卤素或硝基取代的苯基或萘基; 术语卤素是指氟，氯，溴或碘。

    Process
    4.
    发明申请
    Process 有权
    处理

    公开(公告)号：US20100036127A1

    公开(公告)日：2010-02-11

    申请号：US12518416

    申请日：2007-12-12

    申请人： David Alexander Learmonth ,  Antonio Zanotti-Gerosa ,  Gabriela Alexandra Grasa ,  Alexander Beliaev

    发明人： David Alexander Learmonth ,  Antonio Zanotti-Gerosa ,  Gabriela Alexandra Grasa ,  Alexander Beliaev

    IPC分类号： C07F9/50 ,  C07D311/04 ,  C07D233/04

    CPC分类号： C07D311/58

    摘要： A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral catalyst and a source of hydrogen, wherein: X is CH2, oxygen or sulphur; R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R4 is alkyl or aryl, wherein: the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means a phenyl or naphthyl group, optionally substituted by alkyloxy, halogen or nitro group; and the term halogen means fluorine, chlorine, bromine or iodine.

    摘要翻译： 一种制备式A化合物的S或R对映异构体的方法，该方法包括在手性催化剂和氢源存在下使式B化合物进行不对称氢化，其中：X为CH 2，氧或硫 ; R1，R2和R3相同或不同，表示氢，卤素，烷基，烷氧基，羟基，硝基，烷基羰基氨基，烷基氨基或二烷基氨基; 并且R 4是烷基或芳基，其中：术语烷基是指含有1-6个碳原子的直链或支链的烃链，任选地被芳基，烷氧基，卤素，烷氧基羰基或羟基羰基取代; 术语芳基是指任选被烷氧基，卤素或硝基取代的苯基或萘基; 术语卤素是指氟，氯，溴或碘。

    Method for the production of chiral imidazolidin-2-ones
    6.
    发明授权
    Method for the production of chiral imidazolidin-2-ones 失效
    制备手性咪唑烷-2-酮的方法

    公开(公告)号：US07365210B2

    公开(公告)日：2008-04-29

    申请号：US10510439

    申请日：2003-04-08

    申请人： Hansgeorg Ernst ,  Jürgen Koppenhöfer ,  Daniela Klein

    发明人： Hansgeorg Ernst ,  Jürgen Koppenhöfer ,  Daniela Klein

    IPC分类号： C07D233/04

    CPC分类号： C07D233/00

    摘要： The invention relates to a process for preparing chiral imidazolidin-2-ones of the formula I in which R1 is C1-C8-alkyl, cyclohexyl, phenyl, a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto- or CF3-substituted phenyl radical, naphthyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy- or CF3-substituted naphthyl radical, R2 is C1-C8-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a phenyl-C1-C6-alkyl radical which may be substituted by a nitro, C1-C6-alkoxy, methylenedioxy or CF3 radical, and R3 is C1-C12-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, methylenedioxy-, dialkylamino- or CF3-substituted phenyl radical, by reacting a compound of the formula II or the salt thereof in which R1, R2 and R3 have the abovementioned meaning, with urea in the presence of an involatile ammonium salt, wherein the reaction is carried out in the presence of an aprotic polar organic solvent.

    摘要翻译： 本发明涉及一种制备其中R 1是C 1 -C 8 - 的式I的手性咪唑烷-2-酮的方法， 烷基，环己基，苯基，C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 3 - C 6 - 烷氧基 - ，C 1 -C 6 - 烷基巯基或CF 3 - 取代的苯基，萘基或C C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 6 - 烷氧基 - 或CF 3 - 取代的萘基，R 2是C 1 -C 8 - 烷基，C 和R 3具有上述含义，在非挥发性铵盐存在下用脲进行反应，其中反应在非质子极性有机溶剂的存在下进行。

    Method of making highly alkaline solid cleaning compositions
    9.
    发明授权
    Method of making highly alkaline solid cleaning compositions 失效
    制造高碱性固体清洁组合物的方法

    公开(公告)号：US6124250A

    公开(公告)日：2000-09-26

    申请号：US977035

    申请日：1997-11-25

    申请人： Keith E. Olson ,  James Thorson ,  Diane K. Johnson

    发明人： Keith E. Olson ,  James Thorson ,  Diane K. Johnson

    IPC分类号： C07D233/04 ,  C07D233/06 ,  C11D3/02 ,  C11D7/06 ,  C11D17/00 ,  C11D9/44

    CPC分类号： C11D3/044 ,  C11D17/0052 ,  C11D17/0065 ,  C11D7/06

    摘要： The invention provides a process for preparing a highly alkaline, solid cleaning composition in a batch or continuous mixing system, at or below the melting temperature of the alkaline ingredients, and products produced by the process. Preferably, the ingredients are processed in an extruder, and the mixture is extruded directly into a mold or other packaging system for dispensing the cleaning composition. The consistency of the product ranges from that of a fused block solid to a malleable product. The highly alkaline cleaning compositions are useful for warewashing and cleaning hard surfaces, rinsing, sanitizing, deodorizing, laundry detergents, and the like.

    摘要翻译： 本发明提供了一种在分批或连续混合系统中制备高碱性固体清洁组合物的方法，其处于或低于碱性成分的熔融温度或通过该方法生产的产物。 优选地，在挤出机中处理成分，并将混合物直接挤出到用于分配清洁组合物的模具或其它包装系统中。 产品的稠度范围从熔融块状固体到韧性产品的一致性。 高碱性清洁组合物可用于器皿洗涤和清洁硬表面，漂洗，消毒，除臭，衣物洗涤剂等。

    High purity imidazoline-based amphoacetate surfactants
    10.
    发明授权
    High purity imidazoline-based amphoacetate surfactants 有权
    高纯度咪唑啉基二乙酸酯表面活性剂

    公开(公告)号：US6057282A

    公开(公告)日：2000-05-02

    申请号：US378841

    申请日：1999-08-23

    申请人： Bharat Desai ,  Peter Lees ,  Jean-Marc Ricca ,  David J. Tracy

    发明人： Bharat Desai ,  Peter Lees ,  Jean-Marc Ricca ,  David J. Tracy

    IPC分类号： A61K8/00 ,  A61K8/40 ,  A61K8/44 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/10 ,  B01F17/00 ,  B01F17/16 ,  B01F17/22 ,  B01F17/28 ,  C07C233/36 ,  C07C233/38 ,  C07D233/02 ,  C07D233/04 ,  C07D233/14 ,  C11D1/40 ,  C11D1/88 ,  C11D3/43 ,  C11D7/32 ,  C11D7/50 ,  B01F17/18 ,  B01F17/32

    CPC分类号： C11D7/5022 ,  A61K8/442 ,  A61K8/4946 ,  A61Q19/10 ,  A61Q5/02 ,  B01F17/0042 ,  B01F17/0085 ,  C07C233/36 ,  C07C233/38 ,  C07D233/02 ,  C11D1/40 ,  C11D1/88 ,  C11D3/43 ,  C11D7/3209 ,  C11D7/3218 ,  C11D7/5013 ,  C11D7/5018 ,  Y10S516/915

    摘要： Imadazoline-based amphoacetates of higher purity, containing essentially negligible amounts of unalkylated amido amines, lower amounts of glycolic acid salts and monochloroacetate salts, superior to currently available conventional amphoacetates, are provided. This is demonstrated by their improved surface-active properties. Lower inherent irritation properties may be expected due to improved purity.The higher purity amphoacetates can be obtained via processes utilizing precise pH control during the reaction of imidazoline, or its open-chain derivatives, with alkylating agents, e.g. sodium monochloroacetate. The pH can be controlled by adding the base slowly or automatically in response to a pH metering device to maintain a constant pH, or by a series of staged additions which are calculated to maintain pH within a stated range. The reaction may also be carried out by conducting the initial hydrolysis of the imidazoline ring structure, followed by alkylation. These higher-purity amphoacetates contain essentially fully alkylated products and lower amounts of glycolic acid derivatives, even though a ratio of SMCA to substituted imidazoline, or its open-ring derivative, of less than 1.5:1.0 and close to 1.0:1.0 is used.

    摘要翻译： 提供了更高纯度的基于咪达唑啉的两性乙酸盐，其含有基本上可忽略量的未烷基化的酰胺胺，较低量的乙醇酸盐和一氯乙酸盐，优于现有常规的两性乙酸盐。 这通过其改进的表面活性特性证明。 由于纯度的提高，预期会降低固有的刺激性能。 可以通过在咪唑啉或其开链衍生物与烷基化试剂反应期间利用精确的pH控制的方法获得较高纯度的两性乙酸酯。 一氯乙酸钠。 可以通过缓慢或自动地加入碱来控制pH，以响应于pH计量装置以保持恒定的pH，或通过一系列分级添加剂来计算，以将pH保持在规定范围内。 该反应也可以通过进行咪唑啉环结构的初始水解，然后进行烷基化来进行。 尽管SMCA与取代的咪唑啉或其开环衍生物的比例小于1.5：1.0且接近1.0：1.0，但这些较高纯度的两性乙酸盐基本上含有完全烷基化产物和较少量的乙醇酸衍生物。