发明申请
US20050176030A1 Regulated nucleic acids in pathogenesis of Alzheimer's Disease
审中-公开
调节核酸在阿尔茨海默氏病的发病机制中
- 专利标题： Regulated nucleic acids in pathogenesis of Alzheimer's Disease
- 专利标题（中）： 调节核酸在阿尔茨海默氏病的发病机制中
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申请号： US10973858申请日： 2004-10-25
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公开(公告)号： US20050176030A1公开(公告)日： 2005-08-11
- 发明人: Li Gan , Mirella Gonzalez-Zulueta , Shiming Ye , Roman Urfer , Karoly Nikolich
- 申请人： Li Gan , Mirella Gonzalez-Zulueta , Shiming Ye , Roman Urfer , Karoly Nikolich
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/53 ; G01N33/567
摘要：
This invention provides a method for detecting a neurodegenerative disorder or susceptibility to a neurodegenerative disorder in a subject. This invention also provides a method of developing a modulator of an Alzheimer's Disease-associated gene or protein. Also included in the present invention is a method reducing toxic Aβ peptide production by a eukaryotic cell, a method of ameliorating neurotoxicity of Aβ peptide. The present invention further embodies compositions such as Alzheimer's Disease-associated genes, the polypeptides encoded therefrom, gene delivery vehicles, host cells and kits comprising the Alzheimer's Disease-associated genes and/or polypeptides.
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