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公开(公告)号：US20050123962A1
公开(公告)日：2005-06-09
申请号：US10974148
申请日：2004-10-26
申请人： Li Gan , Mirella Gonzalez-Zulueta , Shiming Ye , Roman Urfer , Karoly Nikolich
发明人： Li Gan , Mirella Gonzalez-Zulueta , Shiming Ye , Roman Urfer , Karoly Nikolich
IPC分类号： A61K9/127 , A61K33/00 , A61K39/395 , C07K14/47 , C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/68
CPC分类号： C12Q1/6883 , C07K14/4711 , C12Q2600/142 , C12Q2600/158 , G01N33/6896 , G01N2500/00 , G01N2800/2821
摘要： This invention provides a method for detecting a neurodegenerative disorder or susceptibility to a neurodegenerative disorder in a subject. This invention also provides a method of developing a modulator of an Alzheimer's Disease-associated gene or protein. Also included in the present invention is a method reducing toxic Aβ peptide production by a eukaryotic cell, a method of ameliorating neurotoxicity of Aβ peptide. The present invention further embodies compositions such as Alzheimer's Disease-associated genes, the polypeptides encoded therefrom, gene delivery vehicles, host cells and kits comprising the Alzheimer's Disease-associated genes and/or polypeptides.
摘要翻译： 本发明提供了一种用于检测受试者中神经变性疾病或对神经变性疾病的易感性的方法。 本发明还提供了开发阿尔茨海默病相关基因或蛋白质的调节剂的方法。 本发明还包括减少真核细胞产生毒性的Aβ肽的方法，改善Abeta肽的神经毒性的方法。 本发明进一步体现了诸如阿尔茨海默病相关基因，由其编码的多肽，基因递送载体，宿主细胞和包含阿尔茨海默病相关基因和/或多肽的试剂盒的组合物。
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公开(公告)号：US06924109B2
公开(公告)日：2005-08-02
申请号：US10116437
申请日：2002-04-03
IPC分类号： C12N20060101 , C12N15/10 , C12N15/11 , C12P19/34 , C12Q1/68 , C07H21/04 , C12N1/20 , C12N15/00 , C12N15/63
CPC分类号： C12N15/1034 , C12N15/1072 , C12N15/1079 , C12N15/1093 , C12N15/111 , C12N2310/14 , C12N2320/12 , C12N2330/30
摘要： Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity and then validating the role of the candidate gene in establishment of such a cellular state or activity. Certain methods utilize RNA interference techniques in the validation process.
摘要翻译： 提供了相关基因和基因功能的方法。 这样的方法通常包括选择似乎与特定细胞状态或活性相关的候选基因，然后验证候选基因在建立这种细胞状态或活性中的作用。 某些方法在验证过程中使用RNA干扰技术。
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公开(公告)号：US20050053936A1
公开(公告)日：2005-03-10
申请号：US10491509
申请日：2002-10-17
IPC分类号： C12N20060101 , C12N15/10 , C12N15/11 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1034 , C12N15/1072 , C12N15/1079 , C12N15/1093 , C12N15/111 , C12N2310/14 , C12N2320/12 , C12N2330/30
摘要： Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity and then validating the role of the candidate gene in establishment of such a cellular state or activity. Certain methods utilize RNA interference techniques in the validation process.
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公开(公告)号：US20050176030A1
公开(公告)日：2005-08-11
申请号：US10973858
申请日：2004-10-25
申请人： Li Gan , Mirella Gonzalez-Zulueta , Shiming Ye , Roman Urfer , Karoly Nikolich
发明人： Li Gan , Mirella Gonzalez-Zulueta , Shiming Ye , Roman Urfer , Karoly Nikolich
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/158
摘要： This invention provides a method for detecting a neurodegenerative disorder or susceptibility to a neurodegenerative disorder in a subject. This invention also provides a method of developing a modulator of an Alzheimer's Disease-associated gene or protein. Also included in the present invention is a method reducing toxic Aβ peptide production by a eukaryotic cell, a method of ameliorating neurotoxicity of Aβ peptide. The present invention further embodies compositions such as Alzheimer's Disease-associated genes, the polypeptides encoded therefrom, gene delivery vehicles, host cells and kits comprising the Alzheimer's Disease-associated genes and/or polypeptides.
摘要翻译： 本发明提供了一种用于检测受试者中神经变性疾病或对神经变性疾病的易感性的方法。 本发明还提供了开发阿尔茨海默病相关基因或蛋白质的调节剂的方法。 本发明还包括减少真核细胞产生毒性的Aβ肽的方法，改善Abeta肽的神经毒性的方法。 本发明进一步体现了诸如阿尔茨海默病相关基因，由其编码的多肽，基因递送载体，宿主细胞和包含阿尔茨海默病相关基因和/或多肽的试剂盒的组合物。
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