Invention Application
- Patent Title: Functional mutations in respiratory syncytial virus
- Patent Title (中): 呼吸道合胞病毒的功能突变
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Application No.: US10672302Application Date: 2003-09-26
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Publication No.: US20050176130A1Publication Date: 2005-08-11
- Inventor: Hong Jin , Bin Lu , Xing Cheng , Helen Zhou
- Applicant: Hong Jin , Bin Lu , Xing Cheng , Helen Zhou
- Applicant Address: US CA Mountain View 94043
- Assignee: MedImmune Vaccines, Inc.
- Current Assignee: MedImmune Vaccines, Inc.
- Current Assignee Address: US CA Mountain View 94043
- Main IPC: A61K
- IPC: A61K20060101 ; A61K6/00 ; A61K35/76 ; A61K39/00 ; A61K39/155 ; A61P31/14 ; C07K14/135 ; C12N7/01 ; C12N7/04 ; C12N15/00 ; C12N15/45 ; C12N15/86 ; C12Q1/68 ; C12Q1/70 ; G01N33/569

Abstract:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
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