发明申请
- 专利标题: Benzofuran derivatives, their production and use
- 专利标题(中): 苯并呋喃衍生物,其生产和使用
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申请号: US11081615申请日: 2005-03-17
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公开(公告)号: US20050187238A1公开(公告)日: 2005-08-25
- 发明人: Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
- 申请人: Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
- 优先权: JP345355/1998 19981204; JP345365/1998 19981204
- 主分类号: A61P25/28
- IPC分类号: A61P25/28 ; C07D307/79 ; C07D405/04 ; C07D407/06 ; C07D407/12 ; C07D409/06 ; C07D491/056 ; C07D491/107 ; A61K31/4747 ; C07D493/04
摘要:
Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.
公开/授权文献
- US07456162B2 Benzofuran derivatives, their production and use 公开/授权日:2008-11-25
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