发明申请
- 专利标题： Pulsatile release compositions and methods for enhanced intestinal drug absorption
- 专利标题（中）： 脉动释放组合物和增强肠吸收药物的方法
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申请号： US11000814申请日： 2004-12-01
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公开(公告)号： US20050196443A1公开(公告)日： 2005-09-08
- 发明人: Susan Weinbach , Lloyd Tillman , Richard Geary , Gregory Hardee
- 申请人： Susan Weinbach , Lloyd Tillman , Richard Geary , Gregory Hardee
- 申请人地址： US CA Carlsbad
- 专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： A61K47/12
- IPC分类号： A61K47/12 ; A61K9/20 ; A61K9/22 ; A61K9/24 ; A61K9/26 ; A61K9/28 ; A61K9/42 ; A61K9/48 ; A61K9/52 ; A61K9/54 ; A61K9/66 ; A61K31/7088 ; A61K38/00 ; A61K39/00 ; A61K39/395 ; A61K47/04 ; A61K47/08 ; A61K47/14 ; A61K47/16 ; A61K47/18 ; A61K47/22 ; A61K47/26 ; A61K47/28 ; A61K47/32 ; A61K47/34 ; A61K47/36 ; A61K47/38 ; A61K47/42 ; A61K48/00 ; A61P1/04 ; A61P19/02 ; A61P29/00 ; A61P35/00 ; A61P43/00
摘要：
Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.
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