发明申请
US20050214857A1 Method for displaying loops from immunoglobulin domains in different contexts
审中-公开
在不同上下文中显示来自免疫球蛋白结构域的循环的方法
- 专利标题： Method for displaying loops from immunoglobulin domains in different contexts
- 专利标题（中）： 在不同上下文中显示来自免疫球蛋白结构域的循环的方法
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申请号： US10494829申请日： 2002-12-11
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公开(公告)号： US20050214857A1公开(公告)日： 2005-09-29
- 发明人: Ignace Lasters , Jurgen Pletinckx , Nathalie Boutonnet , Marc Lauwereys , Els Beirnaert
- 申请人： Ignace Lasters , Jurgen Pletinckx , Nathalie Boutonnet , Marc Lauwereys , Els Beirnaert
- 申请人地址： BE Gent B-9052 BE Gent B-9052
- 专利权人： Algonomics N.V.,ABLYNX N.V.
- 当前专利权人： Algonomics N.V.,ABLYNX N.V.
- 当前专利权人地址： BE Gent B-9052 BE Gent B-9052
- 优先权： EP01870274.6 20011211
- 国际申请： PCT/BE02/00189 WO 20021211
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/28 ; C12N15/10 ; C12Q1/68 ; C40B30/04 ; C40B40/02 ; G01N33/68 ; G01N33/53 ; C07K14/705
摘要：
The present invention is related to an isolated polypeptide micro-scaffold displaying immunoglobulin CDR2 or CDR3 polypeptide sequences, comprising a CDR2 or CDR3 polypeptide sequence interconnecting fragments of the adjacent framework polypeptide sequences, which are arranged to form two anti-parallel β-strands. The present invention is further related to a method to search, select or screen for immunoglobulin CDR2 or CDR3 polypeptide sequences that bind to a given antigen or mixture of antigens, comprising the steps of: Creating a CDR library with the method of claim 13 from the genetic information of an individual or group of individuals; Select a CDR, which binds to said antigen or mixture of antigens.
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