发明申请
- 专利标题: Synthesis of pyrrole-2-carbonitriles
- 专利标题(中): 吡咯-2-碳腈的合成
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申请号: US11086061申请日: 2005-03-22
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公开(公告)号: US20050222432A1公开(公告)日: 2005-10-06
- 发明人: Jean Helom , Arkadiy Rubezhov , Anthony Pilcher , Bogdan Wilk
- 申请人: Jean Helom , Arkadiy Rubezhov , Anthony Pilcher , Bogdan Wilk
- 申请人地址: US NJ Madison
- 专利权人: Wyeth
- 当前专利权人: Wyeth
- 当前专利权人地址: US NJ Madison
- 主分类号: C07B43/08
- IPC分类号: C07B43/08 ; C07D207/34 ; C07D207/30
摘要:
The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonitrile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting product with a molar excess of an amide such as N,N-dimethylformamide. The product of this contacting step is then contacted with a molar excess of an organic base to produce a precipitate and a solution phase. The precipitate is then separated from the solution phase and the corresponding pyrrole-2-carbonitrile is isolated from the resulting solution phase.
公开/授权文献
- US07399870B2 Synthesis of pyrrole-2-carbonitriles 公开/授权日:2008-07-15
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