发明申请
US20050227308A1 Method for detecting oxidized forms of soluble guanylate cyclase and a method for screening for activators of soluble guanylate cyclase having oxidized heme iron
失效
用于检测可溶性鸟苷酸环化酶的氧化形式的方法和用于筛选具有氧化血红素铁的可溶性鸟苷酸环化酶活化剂的方法
- 专利标题： Method for detecting oxidized forms of soluble guanylate cyclase and a method for screening for activators of soluble guanylate cyclase having oxidized heme iron
- 专利标题（中）： 用于检测可溶性鸟苷酸环化酶的氧化形式的方法和用于筛选具有氧化血红素铁的可溶性鸟苷酸环化酶活化剂的方法
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申请号： US11144265申请日： 2005-06-03
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公开(公告)号： US20050227308A1公开(公告)日： 2005-10-13
- 发明人: Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
- 申请人： Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
- 申请人地址： DE Frankfurt am Main
- 专利权人： Aventis Pharma Deutschland
- 当前专利权人： Aventis Pharma Deutschland
- 当前专利权人地址： DE Frankfurt am Main
- 优先权： DE19944226.6-41 19990915
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C12Q1/32 ; C12Q1/527 ; C12Q1/66 ; G01N21/78
摘要：
The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
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