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公开(公告)号：US06913898B2
公开(公告)日：2005-07-05
申请号：US10268533
申请日：2002-10-10
Applicant: Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
Inventor： Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
CPC classification number: C12Q1/527 , G01N2333/795 , G01N2500/00
Abstract: The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
Abstract translation: 本发明涉及用于检测其血红素铁处于三价氧化状态的可溶性鸟苷酸环化酶的方法，以及当该可溶性鸟苷酸环化酶的至少一部分的血红素铁时，发现刺激可溶性鸟苷酸环化酶活性的化学物质的方法 被氧化成三价状态，也用于用三价血红素铁检测可溶性鸟苷酸环化酶的诊断辅助剂或试剂盒。 此外，本发明涉及用于检测缺少血红素基团的可溶性鸟苷酸环化酶的方法，以及用于发现刺激缺少血红素基团的可溶性鸟苷酸环化酶的活性的化学物质的方法。
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2.发明授权Method for screening for activators of soluble guanylate cyclase having oxidized heme iron 失效用于筛选具有氧化血红素铁的可溶性鸟苷酸环化酶活化剂的方法公开(公告)号：US07309579B2
公开(公告)日：2007-12-18
申请号：US11144265
申请日：2005-06-03
Applicant: Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
Inventor： Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
IPC: C12Q1/48
CPC classification number: C12Q1/527 , G01N2333/795 , G01N2500/00
Abstract: The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
Abstract translation: 本发明涉及用于检测其血红素铁处于三价氧化状态的可溶性鸟苷酸环化酶的方法，以及当该可溶性鸟苷酸环化酶的至少一部分的血红素铁时，发现刺激可溶性鸟苷酸环化酶活性的化学物质的方法 被氧化成三价状态，也用于用三价血红素铁检测可溶性鸟苷酸环化酶的诊断辅助剂或试剂盒。 此外，本发明涉及用于检测缺少血红素基团的可溶性鸟苷酸环化酶的方法，以及用于发现刺激缺少血红素基团的可溶性鸟苷酸环化酶的活性的化学物质的方法。
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3.发明申请Method for detecting oxidized forms of soluble guanylate cyclase and a method for screening for activators of soluble guanylate cyclase having oxidized heme iron 失效用于检测可溶性鸟苷酸环化酶的氧化形式的方法和用于筛选具有氧化血红素铁的可溶性鸟苷酸环化酶活化剂的方法公开(公告)号：US20050227308A1
公开(公告)日：2005-10-13
申请号：US11144265
申请日：2005-06-03
Applicant: Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
Inventor： Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
CPC classification number: C12Q1/527 , G01N2333/795 , G01N2500/00
Abstract: The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
Abstract translation: 本发明涉及用于检测其血红素铁处于三价氧化状态的可溶性鸟苷酸环化酶的方法，以及当该可溶性鸟苷酸环化酶的至少一部分的血红素铁时，发现刺激可溶性鸟苷酸环化酶活性的化学物质的方法 被氧化成三价状态，也用于用三价血红素铁检测可溶性鸟苷酸环化酶的诊断辅助剂或试剂盒。 此外，本发明涉及用于检测缺少血红素基团的可溶性鸟苷酸环化酶的方法，以及用于发现刺激缺少血红素基团的可溶性鸟苷酸环化酶的活性的化学物质的方法。
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公开(公告)号：US06500631B1
公开(公告)日：2002-12-31
申请号：US09661915
申请日：2000-09-14
Applicant: Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
Inventor： Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
IPC: C12Q148
CPC classification number: C12Q1/527 , G01N2333/795 , G01N2500/00
Abstract: The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
Abstract translation: 本发明涉及用于检测其血红素铁处于三价氧化状态的可溶性鸟苷酸环化酶的方法，以及当该可溶性鸟苷酸环化酶的至少一部分的血红素铁时，发现刺激可溶性鸟苷酸环化酶活性的化学物质的方法 被氧化成三价状态，也用于用三价血红素铁检测可溶性鸟苷酸环化酶的诊断辅助剂或试剂盒。 此外，本发明涉及用于检测缺少血红素基团的可溶性鸟苷酸环化酶的方法，以及用于发现刺激缺少血红素基团的可溶性鸟苷酸环化酶的活性的化学物质的方法。
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