发明申请
- 专利标题: Method for phenotyping using nmr spectroscopy
- 专利标题(中): 使用nmr光谱法进行表型的方法
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申请号: US10512009申请日: 2003-04-15
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公开(公告)号: US20050232864A1公开(公告)日: 2005-10-20
- 发明人: Bill Clark , Klaes Golman , Mathilde Lerche , Mike Looker , Mike O'Sullivan , Albie Santos , Rolf Servin , Mikkel Thaning , Jan-Henrik Ardenkjaer-Larsen
- 申请人: Bill Clark , Klaes Golman , Mathilde Lerche , Mike Looker , Mike O'Sullivan , Albie Santos , Rolf Servin , Mikkel Thaning , Jan-Henrik Ardenkjaer-Larsen
- 优先权: NO20021887 20020419; NO20023358 20020419
- 国际申请: PCT/NO03/00126 WO 20030415
- 主分类号: G01R33/28
- IPC分类号: G01R33/28 ; A61K49/00 ; C12Q1/00 ; C12Q1/26 ; C12Q1/48 ; C12Q1/68 ; G01N20060101 ; G01N24/08 ; G01R33/465
摘要:
The invention relates to methods for phenotyping by determining protein activity in vivo using at least one probe compound and enhancing the nuclear polarisation of NMR active nuclei present in the probe compound (hereinafter termed “hyperpolarisation”) prior to NMR analysis.
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