- 专利标题： Substituted lactams as inhibitors of Abeta protein production
-
申请号： US11005573申请日： 2004-12-06
-
公开(公告)号： US20050234039A1公开(公告)日： 2005-10-20
- 发明人: Qi Han , Hong Liu , Richard Olson , Michael Yang
- 申请人： Qi Han , Hong Liu , Richard Olson , Michael Yang
- 主分类号： C07D243/26
- IPC分类号： C07D243/26 ; A61K31/55 ; A61K31/5513 ; A61P25/28 ; A61P43/00 ; C07D223/12 ; C07D223/18 ; C07D243/12 ; C07D243/24 ; C07D401/04 ; C07D43/02
摘要：
This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
公开/授权文献
- US07276495B2 Substituted lactams as inhibitors of Aβ protein production 公开/授权日：2007-10-02
信息查询
