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    Substituted lactams as inhibitors of Abeta protein production
    1.
    发明申请
    Substituted lactams as inhibitors of Abeta protein production 有权
    取代的内酰胺作为Abeta蛋白质生产的抑制剂

    公开(公告)号：US20070173491A1

    公开(公告)日：2007-07-26

    申请号：US11655637

    申请日：2007-01-19

    申请人： Qi Han ,  Hong Liu ,  Richard Olson ,  Michael Yang

    发明人： Qi Han ,  Hong Liu ,  Richard Olson ,  Michael Yang

    IPC分类号： A61K31/55 ,  A61K31/5513 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

    CPC分类号： C07D401/04 ,  C07D223/12 ,  C07D223/18 ,  C07D243/12 ,  C07D243/24 ,  C07D403/02

    摘要： This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    摘要翻译： 本发明涉及式（I）的新型内酰胺：具有药物和生物影响性质，其药物组合物和使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。 更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

    System and method for generating song transitions using measure groupings
    5.
    发明授权
    System and method for generating song transitions using measure groupings 有权
    使用度量分组生成歌曲转换的系统和方法

    公开(公告)号：US09214144B1

    公开(公告)日：2015-12-15

    申请号：US13950276

    申请日：2013-07-24

    申请人： Michael Yang

    发明人： Michael Yang

    IPC分类号： G10H1/36 ,  G10H1/08

    CPC分类号： G10H1/08 ,  G10H1/46 ,  G10H7/008 ,  G10H2210/381 ,  G10H2210/385 ,  G10H2220/086 ,  G10H2250/035

    摘要： A system and method are provided for mixing song data based on measure groupings. A player or program may recognize measure groupings in a song through identifying cuepoints. The player or program may use the cuepoints and/or other identifiers of measure groupings to generate a transition between the song and other songs. Parts of one or both songs may be time-stretched, or frames may be added or deleted, such that the beats in both songs are substantially aligned during the transition. The system and method may also involve altering the sequence of frames in one or both of the songs, so that the transition may have various sonic qualities as desired by a user. A choice of transition modes may be provided via a user interface that allow the user some control over when and how transitions between songs are executed.

    摘要翻译： 提供了一种基于测量分组来混合歌曲数据的系统和方法。 播放器或程序可以通过识别曲线来识别歌曲中的测量分组。 播放器或程序可以使用度量分组的点和/或其他标识符来产生歌曲和其他歌曲之间的转换。 一首或两首歌曲的部分可能是时间延长的，或者可以添加或删除帧，使得两首歌曲中的节拍在转换期间基本对准。 系统和方法还可以涉及改变一个或两个歌曲中的帧序列，使得转换可以具有如用户所期望的各种声音质量。 转换模式的选择可以通过用户界面来提供，其允许用户对歌曲之间的转换何时以及如何进行控制。

    System and method for generating cuepoints for mixing song data
    6.
    发明授权
    System and method for generating cuepoints for mixing song data 有权
    用于生成用于混合歌曲数据的曲线的系统和方法

    公开(公告)号：US09111519B1

    公开(公告)日：2015-08-18

    申请号：US13282432

    申请日：2011-10-26

    申请人： Michael Yang ,  Neel U. Sukhatme

    发明人： Michael Yang ,  Neel U. Sukhatme

    IPC分类号： G10H1/36 ,  G10H7/00 ,  G10H1/40

    CPC分类号： G10H1/40 ,  G10H2210/385 ,  G10H2220/126 ,  G10H2240/325 ,  G11B27/038 ,  G11B27/322

    摘要： A system and method are provided for generating cuepoints for mixing song data. One or more people may listen to a song and identify measure groupings within the song. The one or more people might generate markings corresponding to these measure groupings and submit the markings to a cuepoint generation system. The markings may then be reconciled into cuepoints that may be used for mixing the song with other song data. In some embodiments, the cuepoints may be adjusted based on characteristics of the particular songs that are to be mixed together.

    摘要翻译： 提供了一种用于产生用于混合歌曲数据的点的系统和方法。 一个或多个人可以听歌曲，并在歌曲中识别测量组。 一个或多个人可能产生与这些度量分组相对应的标记，并将标记提交给一个生成系统。 然后可以将标记调整成可用于将歌曲与其他歌曲数据混合的连接点。 在一些实施例中，可以基于要混合在一起的特定歌曲的特征来调整节点。

    Passive fixation for epicardial lead
    7.
    发明授权
    Passive fixation for epicardial lead 有权
    被动固定为心外膜导联

    公开(公告)号：US09002478B1

    公开(公告)日：2015-04-07

    申请号：US13036821

    申请日：2011-02-28

    申请人： Michael Yang ,  Wenbo Hou ,  Sheldon Williams

    发明人： Michael Yang ,  Wenbo Hou ,  Sheldon Williams

    IPC分类号： A61N1/00 ,  A61N1/05

    CPC分类号： A61N1/0587

    摘要： An epicardial lead is passively fixed in a pericardial space by a passive fixation member. The passive fixation member extends from a distal portion of an epicardial lead and acts against a pericardial layer and an epicardial layer to hold the lead in place. The epicardial lead may include an electrode that is connected to a conductor that extends from a distal portion of the lead. In some embodiments the epicardial lead includes a material that promotes fibrosis to fix the lead to heart tissue. The passive fixation member may include a shocking coil.

    摘要翻译： 心外膜由被动固定构件被动地固定在心包空间中。 被动固定构件从心外膜引导件的远端部分延伸并作用于心包层和心外膜层以将引线保持在适当位置。 心外膜引线可以包括连接到从引线的远端部分延伸的导体的电极。 在一些实施方案中，心外膜引线包括促进纤维化以将引线固定到心脏组织的材料。 被动固定构件可包括震动线圈。

    SCALABLE VIDEO CODEC ENCODER DEVICE AND METHODS THEREOF
    10.
    发明申请
    SCALABLE VIDEO CODEC ENCODER DEVICE AND METHODS THEREOF 审中-公开
    可扩展视频编解码器编码器及其方法

    公开(公告)号：US20120257675A1

    公开(公告)日：2012-10-11

    申请号：US13084142

    申请日：2011-04-11

    申请人： Bob Wang ,  Michael Yang ,  Xiangjun Zhang ,  Xin Guo ,  Xu Gang Zhao

    发明人： Bob Wang ,  Michael Yang ,  Xiangjun Zhang ,  Xin Guo ,  Xu Gang Zhao

    IPC分类号： H04N7/26 ,  H04N7/32

    CPC分类号： H04N19/33 ,  H04N19/42

    摘要： Encoding a video signal according to a scalable video coding (SVC) technique employs two different encoding paths for the base layer and the enhancement layers respectively, whereby the two encoding paths share common hardware encoding modules. For example, a control module can route received video information associated with the base layer directly to the hardware encoder modules for encoding, while routing video information associated with the enhancement layers to an upscaler. The upscaled video information is then provided to the hardware encoder module for processing in similar fashion to the base layer information. The hardware encoder provides encoded video information to another control module, which determines whether to route the information to a hardware or software entropy encoder, based on whether the encoded video information is associated with the base layer or an enhancement layer, respectively.

    摘要翻译： 根据可伸缩视频编码（SVC）技术编码视频信号分别为基本层和增强层使用两种不同的编码路径，由此两个编码路径共享共同的硬件编码模块。 例如，当将与增强层相关联的视频信息路由到升档器时，控制模块可以将接收到的与基本层相关联的视频信息直接路由到硬件编码器模块进行编码。 然后将放大的视频信息提供给硬件编码器模块，以与基本层信息类似的方式进行处理。 硬件编码器将编码视频信息提供给另一个控制模块，该控制模块基于编码视频信息是分别与基本层还是增强层相关联来确定是否将信息路由到硬件或软件熵编码器。