发明申请
- 专利标题： 5-Substituted 2-aryl-4 pyrimidinones
- 专利标题（中）： 5-取代的2-芳基-4-嘧啶酮
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申请号： US11147895申请日： 2005-06-07
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公开(公告)号： US20050234051A1公开(公告)日： 2005-10-20
- 发明人: Kevin Hodgetts , Dario Doller
- 申请人： Kevin Hodgetts , Dario Doller
- 申请人地址： US CT Branford 06405
- 专利权人： Neurogen Corporation
- 当前专利权人： Neurogen Corporation
- 当前专利权人地址： US CT Branford 06405
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61J1/14 ; A61K31/513 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61P1/04 ; A61P1/12 ; A61P1/14 ; A61P3/04 ; A61P5/14 ; A61P9/04 ; A61P9/12 ; A61P15/08 ; A61P17/06 ; A61P19/02 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D239/34 ; C07D239/36 ; C07D239/46 ; C07D239/47 ; C07D239/52 ; C12Q1/02 ; G01N33/15 ; G01N33/58 ; C07D413/02 ; C07D417/02 ; C07D43/02
摘要：
Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
公开/授权文献
- US07169790B2 5-substituted 2-aryl-4-pyrimidinones 公开/授权日：2007-01-30
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