发明申请
US20050244875A1 Method of determining base sequence of DNA or RNA and DNA sequencer
有权
确定DNA或RNA和DNA测序仪碱基序列的方法
- 专利标题： Method of determining base sequence of DNA or RNA and DNA sequencer
- 专利标题（中）： 确定DNA或RNA和DNA测序仪碱基序列的方法
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申请号： US11130801申请日： 2005-05-16
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公开(公告)号： US20050244875A1公开(公告)日： 2005-11-03
- 发明人: Kuniaki Nagayama
- 申请人： Kuniaki Nagayama
- 专利权人： Kuniaki Nagayama
- 当前专利权人： Kuniaki Nagayama
- 优先权： JP2000-351844 20001117
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C12M1/00 ; C12M1/34 ; C12N15/09 ; C12Q1/68 ; G01N33/58 ; H01J37/22 ; H01J37/26 ; G06K9/00
摘要：
Novel DNA sequence determination method and DNA sequencer system providing a sequencing speed 103 to 104 times faster than the current DNA sequencing speed (105 bases per day with a lane at maximum) of the existing DNA sequencer based on electrophoresis. The method includes the step of discriminating base-specific labels of heavy elements using a magnified image of elongated single-chain DNA or RNA produced by a transmission electron microscope (TEM). The DNA sequencer system uses this method. The invention provides a DNA sequencing speed that is higher than the existing speed by 3 or 4 orders of magnitude.