发明申请
US20050245596A1 Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin k inhibitors for the treatment of bone loss
失效
1-（氧代氨基乙酰基）戊基氨基甲酸酯的衍生物作为组织蛋白酶k抑制剂用于治疗骨丢失
- 专利标题： Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin k inhibitors for the treatment of bone loss
- 专利标题（中）： 1-（氧代氨基乙酰基）戊基氨基甲酸酯的衍生物作为组织蛋白酶k抑制剂用于治疗骨丢失
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申请号： US10510469申请日： 2003-04-01
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公开(公告)号： US20050245596A1公开(公告)日： 2005-11-03
- 发明人: David Barrett , John Catalano , David Deaton , Aaron Miller , John Ray , Vicente Samano
- 申请人： David Barrett , John Catalano , David Deaton , Aaron Miller , John Ray , Vicente Samano
- 国际申请： PCT/US03/09893 WO 20030401
- 主分类号： A61K31/341
- IPC分类号： A61K31/341 ; A61K31/365 ; A61K31/40 ; A61K31/4015 ; A61K31/4025 ; A61K31/404 ; A61K31/4155 ; A61K31/416 ; A61K31/4192 ; A61K31/42 ; A61K31/422 ; A61K31/4245 ; A61K31/427 ; A61K31/428 ; A61K31/433 ; A61K31/4439 ; A61K31/4709 ; A61K31/497 ; A61K31/5377 ; A61P19/00 ; A61P19/10 ; A61P43/00 ; C07D207/12 ; C07D207/26 ; C07D207/263 ; C07D207/27 ; C07D207/273 ; C07D207/48 ; C07D307/20 ; C07D307/33 ; C07D401/06 ; C07D403/06 ; C07D403/12 ; C07D405/06 ; C07D405/12 ; C07D409/06 ; C07D409/12 ; C07D413/06 ; C07D413/12 ; C07D413/14 ; C07D417/04 ; C07D417/06 ; C07D417/12 ; C07D417/14 ; C07D43/02 ; C07D45/02
摘要：
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
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