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    Carbamoylpyrolidone derivatives and drugs for senile dementia
    7.
    发明授权
    Carbamoylpyrolidone derivatives and drugs for senile dementia 失效
    氨基甲酰吡咯烷酮衍生物和老年性痴呆药物

    公开(公告)号：US4977167A

    公开(公告)日：1990-12-11

    申请号：US233142

    申请日：1988-08-17

    申请人： Hiromu Matsumura ,  Toshisada Yano ,  Akira Matsushita ,  Masami Eigyo

    发明人： Hiromu Matsumura ,  Toshisada Yano ,  Akira Matsushita ,  Masami Eigyo

    IPC分类号： C07D207/26 ,  C07D207/263 ,  C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10

    CPC分类号： C07D207/27 ,  C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10

    摘要： A compound of the formula: ##STR1## (wherein R is phenoxy optionally substituted by a halogen, methoxy, or methyl group, ##STR2## one of A and B is ##STR3## and the other is >CH.sub.2 : R.sup.1 is hydrogen or C.sub.1 -C.sub.5 alkyl; Z.sup.1 is phenyl, benzyl, or isoxazolyl each optionally substituted by a halogen, methoxy, or methyl group; Z.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, or phenyl optionally mono-, di-, or tri-substituted by a halogen, methoxy, or methyl group; or Z.sup.1 and Z.sup.2 taken together with the adjacent nitrogen atom may form 5-membered heterocyclic group; Z.sup.3 is C.sub.1 -C.sub.5 hydroxyalkyl, di(C.sub.1 -C.sub.5 alkyl)sulfamoyl, 6-membered heterocyclic group, phenyl, benzyl, or phenylsulfonyl each phenyl moiety of the last three members being optionally substituted by a halogen, methoxy, or methyl group; Z.sup.4 is phenyl optionally substituted by a halogen, methoxy, or methyl group or 5- or 6-membered heterocyclic group which is optionally substituted by a halogen, methoxy, or methyl group and which can be optionally condensed with a benzene ring; Z.sup.5 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; Z.sup.6 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; m is an integer from 0 to 2; n is an integer from 2 to 3) or its pharmaceutical acceptable acid addition salt being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.