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发明申请
US20050250166A1 Cdc7-ask kinase complex, substrates of the kinase complex, antibody specific to the substrate, and method of screening compound capable of inhibiting cdc7-ask kinase using the same 审中-公开
Cdc7-激酶复合物，激酶复合物的底物，对底物特异的抗体，以及筛选能够使用其抑制cdc7-激酶的化合物的方法

Cdc7-ask kinase complex, substrates of the kinase complex, antibody specific to the substrate, and method of screening compound capable of inhibiting cdc7-ask kinase using the same
摘要：
The present invention provides methods for measuring the phosphorylation activity of Cdc7-ASK kinase complex by using as an indicator the level of phosphorylation at a phosphorylation site of MCM, which is a substrate of Cdc7-ASK kinase complex. The effects of test compounds on the phosphorylation activity of Cdc7-ASK kinase complex can also be evaluated based on these measurement methods. Compounds that inhibit this phosphorylation activity are useful as anti-cancer agents having superior specificity for cancer.
摘要（中）：

本发明提供了通过使用作为Cdc7-ASK激酶复合物的底物的MCM的磷酸化位点的磷酸化水平作为指标来测量Cdc7-ASK激酶复合物的磷酸化活性的方法。 测试化合物对Cdc7-ASK激酶复合物磷酸化活性的影响也可以基于这些测量方法进行评估。 抑制该磷酸化活性的化合物可用作对癌症具有优异特异性的抗癌剂。

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