发明申请
- 专利标题: Autoinducer molecule
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申请号: US11030569申请日: 2005-01-05
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公开(公告)号: US20050250841A1公开(公告)日: 2005-11-10
- 发明人: James Pearson , Kendall Gray , Luciano Passador , Kenneth Tucker , Anatol Eberhard , Barbara Iglewski , Everett Greenberg
- 申请人: James Pearson , Kendall Gray , Luciano Passador , Kenneth Tucker , Anatol Eberhard , Barbara Iglewski , Everett Greenberg
- 专利权人: University of Iowa,University of Rochester,Ithaca College
- 当前专利权人: University of Iowa,University of Rochester,Ithaca College
- 主分类号: A61K31/366
- IPC分类号: A61K31/366 ; A61K31/381 ; A61K31/382 ; A61K31/4015 ; C12N1/00 ; C12N1/20 ; C12N1/38 ; C12N9/00
摘要:
Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.