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公开(公告)号:US5591872A
公开(公告)日:1997-01-07
申请号:US104487
申请日:1993-08-09
申请人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
发明人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
IPC分类号: C07D307/30 , C07D307/33 , C12N15/67
CPC分类号: C07D307/33 , C07D307/30 , C12N15/67 , Y10S435/875 , Y10S514/851
摘要: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
摘要翻译: 描述了用于绿脓假单胞菌的自动诱导剂分子,例如N-(3-氧代十二烷酰基)高丝氨酸内酯。 分子调节细菌中的基因表达。 还描述了涉及自身诱导剂分子的类似物和/或抑制剂的治疗组合物和治疗方法。 该分子可用于治疗或预防铜绿假单胞菌感染。
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公开(公告)号:US6057288A
公开(公告)日:2000-05-02
申请号:US456864
申请日:1995-06-01
申请人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
发明人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
IPC分类号: C07D307/30 , C07D307/33 , C12N15/67 , A01N37/18 , C07K1/00 , C12N1/00
CPC分类号: C07D307/33 , C07D307/30 , C12N15/67 , Y10S435/875 , Y10S514/851
摘要: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
摘要翻译: 描述了用于绿脓假单胞菌的自动诱导剂分子,例如N-(3-氧代十二酰基)高丝氨酸内酯。 分子调节细菌中的基因表达。 还描述了涉及自身诱导剂分子的类似物和/或抑制剂的治疗组合物和治疗方法。 该分子可用于治疗或预防铜绿假单胞菌感染。
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公开(公告)号:US20050250841A1
公开(公告)日:2005-11-10
申请号:US11030569
申请日:2005-01-05
申请人: James Pearson , Kendall Gray , Luciano Passador , Kenneth Tucker , Anatol Eberhard , Barbara Iglewski , Everett Greenberg
发明人: James Pearson , Kendall Gray , Luciano Passador , Kenneth Tucker , Anatol Eberhard , Barbara Iglewski , Everett Greenberg
IPC分类号: A61K31/366 , A61K31/381 , A61K31/382 , A61K31/4015 , C12N1/00 , C12N1/20 , C12N1/38 , C12N9/00
CPC分类号: A61K31/366 , A61K31/381 , A61K31/382 , A61K31/4015 , C12N1/38 , Y02A50/473 , Y10S435/874 , Y10S435/875
摘要: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
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公开(公告)号:US06936447B1
公开(公告)日:2005-08-30
申请号:US09541873
申请日:2000-04-03
申请人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
发明人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
IPC分类号: A61K31/366 , A61K31/381 , A61K31/382 , A61K31/4015 , C12N1/00 , C12N1/20 , C12N1/38 , C12N9/00
CPC分类号: A61K31/366 , A61K31/381 , A61K31/382 , A61K31/4015 , C12N1/38 , Y02A50/473 , Y10S435/874 , Y10S435/875
摘要: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
摘要翻译: 描述了用于绿脓假单胞菌的自动诱导剂分子,例如N-(3-氧代十二酰基)高丝氨酸内酯。 分子调节细菌中的基因表达。 还描述了涉及自身诱导剂分子的类似物和/或抑制剂的治疗组合物和治疗方法。 该分子可用于治疗或预防铜绿假单胞菌感染。
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