发明申请
US20050250846A1 Non-peptide GnRH agents, pharmaceutical compositions and methods for their use
审中-公开
非肽GnRH剂，药物组合物及其使用方法
- 专利标题： Non-peptide GnRH agents, pharmaceutical compositions and methods for their use
- 专利标题（中）： 非肽GnRH剂，药物组合物及其使用方法
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申请号： US11064211申请日： 2005-06-28
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公开(公告)号： US20050250846A1公开(公告)日： 2005-11-10
- 发明人: Mark Anderson , Lance Christie , Quyen-Quyen Do , Yufeng Hong , Haitao Li , Ranjan Rajapakse , Eric Sun , Eileen Tompkins , Jun Feng , Ved Pathak
- 申请人： Mark Anderson , Lance Christie , Quyen-Quyen Do , Yufeng Hong , Haitao Li , Ranjan Rajapakse , Eric Sun , Eileen Tompkins , Jun Feng , Ved Pathak
- 主分类号： C07D307/68
- IPC分类号： C07D307/68 ; A61K31/341 ; A61K31/435 ; A61K31/4353 ; A61K31/437 ; A61K31/443 ; A61K31/4709 ; A61K31/495 ; A61K31/501 ; A61K31/506 ; A61K31/519 ; A61K31/53 ; A61P5/02 ; A61P5/04 ; A61P13/08 ; A61P15/00 ; A61P15/08 ; A61P15/16 ; A61P25/20 ; A61P31/00 ; A61P31/18 ; A61P35/00 ; A61P37/02 ; A61P43/00 ; C07D307/46 ; C07D405/12 ; C07D405/14 ; C07D471/04 ; C07D495/04 ; C07D519/00 ; A61K31/34 ; C07D307/02
摘要：
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
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