公开(公告)号：US20240279184A1

公开(公告)日：2024-08-22

申请号：US18565844

申请日：2022-06-03

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITÉ DE STRASBOURG ,  UNIVERSITE DE HAUTE ALSACE

发明人： Elisabeth DAVIOUD-CHARVET ,  Maxime DONZEL ,  Matthieu ROIGNANT ,  Mourad ELHABIRI

IPC分类号： C07D239/30 ,  C07C41/30 ,  C07C43/275 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/84 ,  C07D215/14 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D277/62 ,  C07D307/42 ,  C07D307/46 ,  C07D333/22 ,  C07D405/12

CPC分类号： C07D239/30 ,  C07C41/30 ,  C07C43/275 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/84 ,  C07D215/14 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D277/62 ,  C07D307/42 ,  C07D307/46 ,  C07D333/22 ,  C07D405/12

摘要： A compound having the formula (I):




wherein:



R1 is selected from the group consisting of: H, F, (C1-C6)alkoxy, and halo(C1-C6)alkyl; and
R2 is an optionally substituted heteroaryl group, as well as processes for the preparation of the compound, and intermediate compounds.

公开(公告)号：US20230032460A1

公开(公告)日：2023-02-02

申请号：US17687009

申请日：2022-03-04

申请人： Origin Materials Operating, Inc.

发明人： Alex B. WOOD ,  Makoto N. MASUNO ,  Ryan L. SMITH ,  John BISSELL ,  Dimitri A. HIRSCH-WEIL ,  Robert Joseph ARAIZA ,  Daniel R. HENTON ,  James H. PLONKA

IPC分类号： C07D307/46 ,  C07D307/50 ,  B01J27/10

摘要： The present disclosure provides methods to produce 5-(halomethyl)furfural, including 5-(chloromethyl)furfural, by acid-catalyzed conversion of C6 saccharides, including isomers thereof, polymers thereof, and certain derivatives thereof. The methods make use of acids with lower concentrations, and allows for conversion of sugars into 5-(halomethyl)furfural at higher temperatures and faster reaction or residence times.

公开(公告)号：US20210403434A1

公开(公告)日：2021-12-30

申请号：US17468035

申请日：2021-09-07

申请人： King Abdulaziz University ,  Virginia Commonwealth University

发明人： Abdelsattar Mansour Ebeid Omar ,  Moustafa El-Sayed El-Araby ,  Martin K. Safo

IPC分类号： C07D233/64 ,  A61P7/00 ,  C07D307/46

摘要： 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

公开(公告)号：US20210388007A1

公开(公告)日：2021-12-16

申请号：US17336330

申请日：2021-06-02

申请人： WUHAN UNIVERSITY

发明人： Xiao SHEN ,  Xiang CHEN ,  Xingxing GONG

IPC分类号： C07F7/08 ,  C07C67/31 ,  C07D209/34 ,  C07C45/64 ,  C07D307/46 ,  C07C231/12 ,  C07C253/30 ,  C07C29/32 ,  C07J1/00 ,  C07D317/54 ,  C07C315/04 ,  C07J71/00

摘要： The present disclosure relates to a compound and a preparation method and application thereof, the compound having a chemical structure formula of: wherein M in the formula is selected from a group consisting of CF3 or CF2H, and R1, R2, and R3 are each independently selected from a group consisting of aryl, heteroaryl, and alkyl. The compound provided by the present disclosure can be used as a trifluoroethanolation reagent or difluoroethanolation reagent as synthetic intermediates of many organic compounds, and some of the compounds have pharmaceutical activity. The preparation steps of such compounds are simplified, with mild synthesis conditions and wide applicability of substrates.

公开(公告)号：US11136302B2

公开(公告)日：2021-10-05

申请号：US16616675

申请日：2018-05-09

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： Chandrashekhar Vasant Rode ,  Suhas Hanmant Shinde

IPC分类号： C07D307/46

摘要： The present invention discloses a single step process for the synthesis of furan derivative from carbohydrate comprises stirring the reaction mixture of carbohydrate in solvent in presence of catalyst at temperature in the range of 170 to 190° C. for the period in the range of 23 to 25 hrs to afford corresponding furan derivative.

公开(公告)号：US20210300884A1

公开(公告)日：2021-09-30

申请号：US17210196

申请日：2021-03-23

申请人： Oregon State University

发明人： Konstantinos Goulas ,  Nicholas L. Gadinas ,  Kyle B. Reem

IPC分类号： C07D307/36 ,  C07D307/46 ,  C07D307/42

摘要： Disclosed herein is a method for making oleofuran compounds according to formula 3 from a furan aldehyde or ketone and a fatty alcohol. The method comprises combining the furan compound and the fatty acid in the presence of a first catalyst to form an intermediate compound, and exposing the intermediate compound to hydrogen in the presence of a second catalyst to form the oleofuran compound. The hydrogen may be either hydrogen gas or hydrogen provided by a hydrogen donor.

公开(公告)号：US20210292290A1

公开(公告)日：2021-09-23

申请号：US17259632

申请日：2019-07-12

申请人： Novamont S.P.A.

发明人： Luigi Capuzzi ,  Giuseppina Carotenuto ,  Adriano Ferrari

IPC分类号： C07D307/46 ,  B01D61/02 ,  B01D61/58 ,  B01D61/44

摘要： The present invention relates to a process for the production and separation of 5-hydroxymethylfurfural (HMF) comprising the steps of: (1) dehydrating at least one saccharide selected from the group consisting of monosaccharides having 6 carbon atoms and disaccharides, oligosaccharides and polysaccharides formed from units having 6 carbon atoms or mixtures thereof, in the presence of water and of at least one quaternary ammonium salt, at a temperature between 80-130° C., obtaining a reaction mixture comprising the quaternary ammonium salt, HMF and any unreacted saccharide; and (2) subjecting the said reaction mixture to at least one membrane separation operation selected in the group consisting of nanofiltration, reverse osmosis, electrodialisis and their combinations, obtaining an aqueous permeate comprising HMF and a retentate comprising quaternary ammonium salt, wherein both the dehydration of step (1) and the separation operations of step (2) are carried out in the absence of organic solvents.

公开(公告)号：US20210238127A1

公开(公告)日：2021-08-05

申请号：US17233488

申请日：2021-04-18

申请人： National Institute of Biological Sciences, Beijing

发明人： Niu Huang ,  Shiming Peng

IPC分类号： C07C255/34 ,  A61P25/28 ,  A61P3/04 ,  C07D277/30 ,  C07D277/46 ,  C07D213/57 ,  C07D237/14 ,  C07D239/36 ,  C07D241/24 ,  C07D251/16 ,  C07D241/52 ,  C07D471/04 ,  C07D213/80 ,  C07D241/20 ,  C07D285/08 ,  C07D295/185 ,  C07D241/12 ,  C07D249/08 ,  C07D261/12 ,  C07D239/42 ,  C07D215/233 ,  C07D277/56 ,  C07D249/12 ,  C07D211/82 ,  C07D487/04 ,  C07D235/08 ,  C07D231/14 ,  C07D209/08 ,  C07D239/26 ,  C07D233/56 ,  C07D277/24 ,  C07D261/08 ,  C07D307/46 ,  C07D257/04 ,  C07D213/75 ,  C07D277/64 ,  C07C255/43

摘要： The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US20210163516A1

公开(公告)日：2021-06-03

申请号：US17173500

申请日：2021-02-11

申请人： Johnson Matthey Public Limited Company

发明人： Thomas Colacot ,  Ruishan Chow ,  Andrew Jon DeAngelis

IPC分类号： C07F15/00 ,  C07D215/38 ,  C07B37/04 ,  C07B43/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D471/04 ,  C07D295/096 ,  C07D213/127 ,  C07D213/24 ,  C07D213/50 ,  C07D213/56 ,  C07D307/46 ,  C07C45/68 ,  C07C17/32

摘要： The present invention provides a palladium(II) complex of formula (1). R12, m, and X are described in the specification. The invention also provides a process for the preparation of the complex, and its use in carbon-carbon and carbon-heteroatom coupling reactions.

公开(公告)号：US20200223845A1

公开(公告)日：2020-07-16

申请号：US16798859

申请日：2020-02-24

申请人： Katholieke Universiteit Leuven

发明人： Dorothée Bardiot ,  Gunter Carlens ,  Kai Dallmeier ,  Suzanne Kaptein ,  Mohamed Koukni ,  Arnaud Marchand ,  Johan Neyts ,  Wim Smets

IPC分类号： C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D223/04 ,  C07D231/12 ,  C07D333/22 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D261/08 ,  C07D207/06 ,  C07D265/30 ,  C07D267/10 ,  C07D275/02 ,  C07D498/04 ,  C07D279/12 ,  A61K31/415 ,  C07D409/12 ,  A61K31/34 ,  A61K31/381 ,  A61K31/40 ,  C07D207/323 ,  C07D403/06 ,  C07D405/12 ,  C07D407/06 ,  C07D271/04 ,  C07D285/06 ,  A61K31/4439 ,  C07D403/12 ,  C07D243/06 ,  A61K31/437 ,  C07D211/06 ,  A61K45/06 ,  C07D513/04 ,  C07D407/04 ,  C07D307/46 ,  C07D207/335 ,  C07D211/16 ,  C07D241/04 ,  C07D243/08 ,  C07D263/32 ,  C07D271/08 ,  C07D277/28 ,  C07D285/10 ,  C07D307/52 ,  C07D413/12 ,  C07D487/04

摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.