发明申请
US20050261245A1 Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
失效
二芳基-2-（5h） - 呋喃酮作为环加氧酶-2抑制剂的一氧化氮释放前药
- 专利标题： Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
- 专利标题（中）： 二芳基-2-（5h） - 呋喃酮作为环加氧酶-2抑制剂的一氧化氮释放前药
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申请号： US10521075申请日： 2003-07-24
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公开(公告)号： US20050261245A1公开(公告)日： 2005-11-24
- 发明人: Carl Berthelette , Nicholas Lachance , Lianhai Li , Claudio Sturino , Zhaoyin Wang , Robert Young , Claude Dufresne
- 申请人： Carl Berthelette , Nicholas Lachance , Lianhai Li , Claudio Sturino , Zhaoyin Wang , Robert Young , Claude Dufresne
- 国际申请： PCT/CA03/01115 WO 20030724
- 主分类号： A61K31/422
- IPC分类号： A61K31/422 ; A61K31/427 ; A61K31/496 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61K31/675 ; A61P29/00 ; C07C317/46
摘要：
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
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