摘要:
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
摘要:
The invention encompasses novel compounds of Formula (I) and Formula (II), which are nitric oxide-releasing prodrugs useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) or Formula (II). The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
摘要:
The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要:
The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要:
A communication system comprising a base station and two or more terminals configured for communicating with the base station by means of a communications protocol, wherein: the communications protocol operates in a frequency band to which unlicensed access is permitted; and the terminals are configured for unattended operation with the base station.
摘要:
Methods, computer programs, and apparatus for applying a layer of cushion gum to a tire casing in preparation for the retreading of the tire casing, the steps of the methods including selecting one of a plurality recipes for applying cushion gum based on one of a size, model and shape of the tire casing; pressurizing the tire casing to a predetermined pressure based on the recipe; crushing the tire casing by an extruder head a predetermined percentage of the tire casing radius or a predetermined distance, the predetermined percentage based on the recipe; and extruding the cushion gum from the extruder head. The extruder head may be translatable by way of a screw drive.
摘要:
A method for synchronising a receiving device with a transmitting device in a wireless communication network comprising forming a synchronisation sequence that has a frequency spectrum comprising peaks at multiple discrete fundamental frequencies, a signal power of the synchronisation sequence being concentrated at those frequencies, and transmitting said synchronisation sequence from the transmitting device to the receiving device.
摘要:
Improved apparatus and methods for collecting debris generated during a tire buffing operation on a tire buffing machine, the tire buffing machine having a cutting head cutting surface rotatable about a cutting head axis. The system includes a rotatable shroud being rotatable about a shroud axis, the shroud comprising a side member surrounding a majority of the cutting head cutting surface, a cutting head access window to expose the cutting head for buffing the tire casing, and a vacuum suction port that is adjacent to the cutting head access window. The system may further include a driver to rotate the shroud during buffing, wherein rotating the shroud during buffing aligns the vacuum suction port with the projected path of debris being discharged from the cutting head cutting surface.
摘要:
This invention relates to a method for the production of graphene oxide and its use in various applications. The invention provides a method for the preparation of graphene oxide which involves treating a mixture of graphene oxide and impurities with a solution of a base. The impurities in the graphene oxide include oxygen-containing species that are associated with it i.e. bound to the graphene oxide but which are not covalently bonded to the graphene. The graphene oxide of the present invention has improved purity relative to the poorly characterised graphene oxide that is produced by existing methods.
摘要:
A computing system with an adaptive input mechanism that facilitates intuitive and powerful user/computer interaction is disclosed. One example embodiment includes a logic subsystem, a display link configured to connect a display subsystem to the logic subsystem, and an adaptive device link configured to operatively couple an adaptive device to the logic subsystem. The embodiment further includes an active desktop to host an active application and present the active application on the display subsystem, the active application having active focus. An active-desktop director may pass non-adaptive-device input to the active application having active focus. The embodiment further includes a hidden desktop to host a hidden application having hidden focus specific to the adaptive device while the active application has active focus on the active desktop. A hidden-desktop director may route adaptive-device input to the hidden application having hidden focus.