发明申请
- 专利标题： VR1 receptors and uses thereof
- 专利标题（中）： VR1受体及其用途
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申请号： US11076431申请日： 2005-03-09
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公开(公告)号： US20050266435A1公开(公告)日： 2005-12-01
- 发明人: David Hackos , Tito Serafini , Nina Orike
- 申请人： David Hackos , Tito Serafini , Nina Orike
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C07K16/28 ; C12N15/12 ; C12Q1/68 ; G01N33/53 ; G01N33/567 ; G01N33/68 ; G01N33/94
摘要：
The present invention relates to nucleic and amino acid sequences encoding vanilloid receptors which are vanilloid-insensitive. The present invention provides mutant vanilloid receptors which are insensitive to vanilloid, but which are capable of responding to low pH, heat and other receptor modulators. The invention particularly provides mutant vanilloid insensitive human VR1 receptors. The invention also relates to methods and assays for screening for vanilloid receptor modulators that act independent of the vanilloid binding site and modulate receptor signals independent of a functional vanilloid, or capsaicin, response. The invention further provides methods of modulating the vanilloid receptor, independent of vanilloid response.
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